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Acta Chimica Sinica ›› 2010, Vol. 68 ›› Issue (08): 775-780. Previous Articles     Next Articles

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稀土、钨酸、1,3-二苯基-4-吡唑甲醛缩异烟肼三元配合物的合成、表征及抗癌活性的研究

夏庆春，何其庄*，许东芳，李兴玉，孙大志   

  1. (上海师范大学生命与环境科学学院 上海 200234)
  • 投稿日期:2009-09-14 修回日期:2009-11-28 发布日期:2009-12-30
  • 通讯作者: 何其庄 E-mail:hqz@shnu.edu.cn
  • 基金资助:

    国家自然科学基金(20671063)、上海市稀土功能材料重点实验室(07dz22303)、上海市重点学科建设项目(S30406)上海师范大学重点学科(DZL711) 资助项目.

Synthesis, Characterization and Anticancer Activity of Rare Earth Complexes with 1,3-Diphenyl-4-pyrazole-formyl Isoniazidylhydrazone and Tungstic Acid

JIA Qiang-Chun, HE Ji-Peng, HU Dong-Fang, LI Xin-Yu, SUN Da-Zhi   

  1. (Department of Chemistry, Shanghai Normal University, Shanghai 200234)
  • Received:2009-09-14 Revised:2009-11-28 Published:2009-12-30

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Using a reflux condensation method and a low-temperature solid phase method, five kinds of new ternary complexes were synthesized with rare earth chloride, tungstic acid and 1,3-diphenyl-4-pyrazole- formyl isoniazidylhydrazone. Their compositions were characterized by elemental analysis, molar conductance, FT-IR, UV-vis, TG-DTA, TC-ICP, and XPS, and confirmed to be: Na[RE(HL)(WO4)2]•6H2O (HL: 1,3-diphenyl-4-pyrazole-formyl isoniazidylhydrazone). MTT was used to study the complexes cytotoxicity against to K562 tumor cells and morphological observation. The results show that the complexes IC50 were 25 μg/mL, flow cytometry results showed that the best concentration apoptosising on cancer cells were 12.5 μg/mL. Cancer cells were arrested in S phase, inhibitting cells mitosis process.

Key words: complex, anti-tumor, flow