Controllable Synthesis and Release Properties of Methotrexatum/Layered Double Hydroxide Compounds

doi:10.6023/A12030055

Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (20): 2162-2168.DOI: 10.6023/A12030055 Previous Articles Next Articles

Article

甲氨蝶呤/层状双金属氢氧化物的粒径调控及缓释性能研究

齐凤林, 李淑萍, 张晓晴

江苏省生物功能材料重点实验室南京师范大学化学与材料科学学院南京 210097

投稿日期:2012-03-25 发布日期:2012-08-23
通讯作者: 李淑萍 E-mail:lishuping@njnu.edu.cn
基金资助:
项目受国家自然科学基金(No. 21073093)、高等学校博士点专项科研基金(No. 20103207120006)和江苏高校优势学科建设工程资助.

Controllable Synthesis and Release Properties of Methotrexatum/Layered Double Hydroxide Compounds

Qi Fenglin, Li Shuping, Zhang Xiaoqing

Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China

Received:2012-03-25 Published:2012-08-23
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21073093), Research Fund for the Doctoral Program of Higher Education of China (No. 20103207120006) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

1. Controllable Synthesis and Release Properties of Methotrexatum/Layered Double Hydroxide Compounds.PDF(121KB)

Abstract

The methotrexatum/layered double hydroxide (MTX/LDH) compounds with different particle sizes were prepared by controlling the dropping speed of precipitator, using the coprecipitation method in alcohol-water solvent and NH₃稨₂O as precipitator. The influence of the dropping speed of precipitator on the structure and morphologies of MTX/LDHs was systematically characterized by X-ray diffraction (XRD), transmission electron micrograph (TEM) and fourier transform infrared spectroscopy (FT-IR). The results indicated that MTX anions were intercalated into the LDH interlayers with a declined monolayer and the angle of inclination changed with the variation of the dropping speed of precipitator. Furthermore, the dropping speed of precipitator affected the crystallinity and particle size as well as arrangement way of MTX in LDH interlayers, when the dropping speed is 0.100 mL/s, the products have the highest crystallinity and the maximum diameter. All the MTX/LDHs particles exhibited hexagonal platelet morphology with round corner and good monodispersity. At last, the release properties of MTX/LDHs with different particle sizes were studied in phosphate buffer. The results indicated that the smaller nanoparticles have higher drug-loading capacity than those of the larger ones and when the angles of inclination keep almost constant, the smaller nanoparticles have the longer release time than those of the larger ones. In addition, four kinetic models (first-order equation, Higuchi equation, Bhaskar equation and Ritger-Peppas equation) were used to study the release kinetics of MTX from the LDH interlayers, and it was found that the mechanism for drug release can be well described by the Ritger-Peppas equation, revealing that the release mechanism of MTX/LDH belongs to drug diffusion and Fickian diffusion is the rate limiting step. First of all, we have explored a new way to synthesize LDH compounds with different particle size in the guarantee of the angles of inclination of anions in interlayer keeping similar.

Key words: nanoparticles, layered compound, release property, dropping speed of precipitator, methotrexatum

Cite this article

Qi Fenglin, Li Shuping, Zhang Xiaoqing. Controllable Synthesis and Release Properties of Methotrexatum/Layered Double Hydroxide Compounds[J]. Acta Chimica Sinica, 2012, 70(20): 2162-2168.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

share this article

References

[1] Kwak, S. Y.; Jeong, Y. J.; Park, J. S. Solid State Ionics 2002, 151, 229.

[2] Zhang, H.; Qi, R.; Duan, X. Chin. J. Inorg. Chem. 2002, 18, 833. (张慧, 齐荣, 段雪, 无机化学学报, 2002, 18, 833.)

[3] Zhang, X.; Zhang, H.; Wei, M.; Evans, D. G.; Duan, X. Chem. J. Chin. Univ. 2004, 25, 1869. (张娴, 张慧, 卫敏, Evans, D. G., 段雪, 高等学校化学学报, 2004, 25, 1869.)

[4] Nie, H.-Q.; Hou, W.-G. Acta Phys.-Chim. Sin. 2011, 27, 1783. (聂宏骞, 侯万国, 物理化学学报, 2011, 27, 1783.)

[5] Jia, C.-X.; Zhang, X.-Q.; Li, S.-P. Chin. J. Chem, 2012, 30, 277.

[6] Choy, J. H.; Kwak, S. Y.; Jeong, Y. J.; Park, J. S. Angew. Chem. Int. Ed. 2000, 39, 4041.

[7] Yang, J. H.; Han, Y. S.; Park, M.; Park, T.; Hwang, S. J.; Choy, J. H. Chem. Mater. 2007, 19, 2679.

[8] Katherine, M. T.; Scott, S. R.; Emmanuel, G. P. J. Controlled Release 2004, 95, 501.

[9] Kwak, S. Y.; Kriven, W. M.; Wallig, M. A.; Choy, J. H. Biomaterials 2004, 25, 5995.

[10] Oh, J. M.; Park, M.; Kim, S. T.; Jung, J. Y.; Kang, Y. G.; Choy, J. H. J. Phys. Chem. Solids 2006, 67, 1024.

[11] Tang, F.; Zheng, G.-H.; Yao, Q.-Z.; Lv, G.; Zhou, W.-F.; Wang, Q.-J. Acta Chim. Sinica 2006, 64, 249. (唐锋, 郑国海, 姚其正, 吕刚, 周卫芬, 王秋娟, 化学学报, 2006, 64, 249.)

[12] Xue, Y.-H.; Zhang, R.; Sun, X.-Y.; Wang, S.-L. Chin. J. Pharm. 2007, 38, 63. (薛燕华, 张蕤, 孙晓宇, 汪世龙, 中国医药工业杂志, 2007, 38, 63.)

[13] Oh, J. H.; Choi, S. J.; Kim, S. T.; Choy, J. H. Bioconjugate Chem. 2006, 17, 1411.

[14] Du, X.-Y.; Chen, Y.-Z.; Ma, Y.-X.; Li, F. Appl. Chem. Ind. 2008, 37, 1449. (杜雪岩, 陈尹泽, 马应霞, 李芳, 应用化工, 2008, 37, 1449.)

[15] Wang, J.-Q.; Li, X.; Li, S.-P.; Zhong, H. Acta Chim. Sinica 2011, 69, 137. (王继芹, 李鑫, 李淑萍, 仲慧, 化学学报, 2011, 69, 137.)

[16] Meng, J.-H.; Zhang, H.; Evans, D. G.; Duan, X. Chin. Sci. Bull. 2005, 50, 208. (孟锦宏, 张慧, Evans, D. G., 段雪, 科学通报, 2005, 50, 208.)

[17] Aisawa, S.; Ohnuma, Y.; Hirose, K.; Takahashi, S.; Hirahara, H.; Narita, E. Appl. Clay Sci. 2005, 28, 137.

[18] Aisawa, S.; Takahashi, S.; Ogasawara, W.; Umetsu, Y.; Narita, E. J. Solid State Chem. 2001, 162, 52.

[19] Choy, J. H.; Jung, J. S.; Oh, J. M.; Parka, M.; Jeong, J.; Kang, Y. K.; Han, O. J. Biomaterials 2004, 25, 3059.

[20] Li, B.-X.; He, J.; Evans, D. G.; Duan, X. Appl. Clay Sci. 2004, 27, 199.

[21] Xu, Z.-P.; Lu, G.-Q. Pure Appl. Chem. 2006, 78, 1771.

[22] Zhang, H.; Pan, D. K.; Duan, X. J. Phys. Chem. C 2009, 113, 12140. Li, F.-S.; Jin, L.; Han, J.-B.; Wei, M.; Li, C.-J. Ind. Eng. Chem. Res. 2009, 48, 5590.

甲氨蝶呤/层状双金属氢氧化物的粒径调控及缓释性能研究

Controllable Synthesis and Release Properties of Methotrexatum/Layered Double Hydroxide Compounds

PDF

Supporting Info.

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Xufa He, Kangle Jia, Longfei Yu, Mingjie Liu, Xiaoshan Zheng, Huanling Li, Jinlan Xin, Linjia Huang. pH-Responsive Pickering Emulsions Synergistically Stabilized by Maleopimaric Acid and Alumina Nanoparticles [J]. Acta Chimica Sinica, 2022, 80(6): 765-771.
[2]	Ruomei Liu, Yanhui Feng, Zhuo Li, Shan Lu, Tianyong Guan, Xingjun Li, Yan Liu, Zhuo Chen, Xueyuan Chen. A Novel Near-infrared Responsive Lanthanide Upconversion Nanoplatform for Drug Delivery Based on Photocleavage of Cypate^※ [J]. Acta Chimica Sinica, 2022, 80(4): 423-427.
[3]	Junmin Chen, Chengqian Cui, Hanlin Liu, Guodong Li. Study on the Selective Hydrogenation of Quinoline Catalyzed by Composites of Metal-Organic Framework and Pt Nanoparticles^※ [J]. Acta Chimica Sinica, 2022, 80(4): 467-475.
[4]	Jinyuan Zhao, Qian Zhang, Jian Wang, Qi Zhang, Heng Li, Yaping Du. Advances in the Scavenging Materials for Reactive Oxygen Species [J]. Acta Chimica Sinica, 2022, 80(4): 570-580.
[5]	Yanran Li, Zigui Wang, Zhaohui Tang. Water Soluble IR-780 Polymer for Mitochondria-Targeted Photodynamic Therapy^※ [J]. Acta Chimica Sinica, 2022, 80(3): 291-296.
[6]	Jinghuang Chen, Tian Meng, Lie Wu, Hengchong Shi, Fan Yang, Jian Sun, Xiurong Yang. Study on Synthesis and Antibacterial Properties of AgNPs@ZIF-67 Composite Nanoparticles^※ [J]. Acta Chimica Sinica, 2022, 80(2): 110-115.
[7]	Ju Huang, Zhen Li, Zhihong Liu. Functionalized Upconversion Nanoparticles for Disassembly of β‑Amyloid Aggregation with Near-Infrared Excitation [J]. Acta Chimica Sinica, 2021, 79(8): 1049-1057.
[8]	Heqi Gao, Di Jiao, Hanlin Ou, Jingtian Zhang, Dan Ding. High Performance Aggregation-Induced Emission Nanoprobes for Image-Guided Cancer Surgery [J]. Acta Chimica Sinica, 2021, 79(3): 319-325.
[9]	Xiaomeng Zhang, Xiya Li, Wanfeng Xiong, Hongfang Li, Rong Cao. Ultrafine Platinum Nanoparticles Derived from Supramolecular Crystal for Catalytic Hydrogenation of Nitroarenes [J]. Acta Chimica Sinica, 2021, 79(2): 180-185.
[10]	Wang Peipei, Liang Tao, Zuo Miaomiao, Li Zhen, Liu Zhihong. A Ratiometric Upconversion Nanoprobe for Detection of HNO Based on Luminescence Resonance Energy Transfer [J]. Acta Chimica Sinica, 2020, 78(8): 797-804.
[11]	Yan Tao, Liu Zhenhua, Song Xinyue, Zhang Shusheng. Construction and Development of Tumor Microenvironment Stimulus-Responsive Upconversion Photodynamic Diagnosis and Treatment System [J]. Acta Chimica Sinica, 2020, 78(7): 657-669.
[12]	Jin Fengming, Dong Hongwei, Zhao Yan, Zhuang Shengli, Liao Lingwen, Yan Nan, Gu Wanmiao, Zha Jun, Yuan Jinyun, Li Jin, Deng Haiteng, Gan Zibao, Yang Jinlong, Wu Zhikun. Module Replacement of Gold Nanoparticles by a Pseudo-AGR Process [J]. Acta Chimica Sinica, 2020, 78(5): 407-411.
[13]	Wu Yan, Pang Aimin, Hu Lei, He Gensheng, Zhang Yingying, Zhang Lixiong, Li Minghai, Ma Zhenye. Preparation of α-Fe₂O₃/(IPDI-HTPB) Composite Nanoparticles and Their Catalytic Performance [J]. Acta Chimica Sinica, 2020, 78(4): 337-343.
[14]	Li Wei, Ran Tiecheng, Zhang Yu, He Wei, Ma Jifei, Wang Qisheng, Zhang Jichao, Zhu Ying. SiO₂-Mediated High-efficiency Enrichment of 5 nm Gold Nanoparticles and Their Catalytic Activity [J]. Acta Chimica Sinica, 2020, 78(2): 170-176.
[15]	Sun Yanhui, Qi Youxiao, Shen You, Jing Cuijie, Chen Xiaoxiao, Wang Xinxing. Preparation of Electrochemical Sensor Based on RGO-Au-ZIF-8 Composite and Its Application in Simultaneous Detection of Lead Ions and Copper Ions [J]. Acta Chimica Sinica, 2020, 78(2): 147-154.