Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System

doi:10.6023/A16020096

Acta Chim. Sinica ›› 2016, Vol. 74 ›› Issue (5): 401-409.DOI: 10.6023/A16020096 Previous Articles Next Articles

Review

肽类树状大分子的合成及其在药物传输系统中的应用

张少飞^a,b, 杨建东^b, 柳明珠^a, 吕少瑜^a, 高春梅^a, 吴灿^a, 朱召彦^a

a 功能有机分子化学国家重点实验室兰州大学化学化工学院兰州 730000;
b 陇南师范高等专科学校陇南 742500

投稿日期:2016-02-22 发布日期:2016-04-26
通讯作者: 柳明珠 E-mail:mzliu@lzu.edu.cn
基金资助:
项目受国家自然科学基金(Nos. 51541304, 51273086)、教育部高等学校博士学科点专项科研基金(No. 20130211110017)和陇南师范高等专科学校校级重点科研项目(No. 2014LSZK01004)资助.

Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System

Zhang Shaofei^a,b, Yang Jiandong^b, Liu Mingzhu^a, Lü Shaoyu^a, Gao Chunmei^a, Wu Can^a, Zhu Zhaoyan^a

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000;
b Longnan Teacher's College, Longnan 742500

Received:2016-02-22 Published:2016-04-26
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 51541304, 51273086), Special Doctorial Program Fund from the Ministry of Education of China (Grant No. 20130211110017) and Key Research Project of Longnan Teacher's College (Grant No. 2014LSZK01004).

Dendrimers are a novel polymer material, which have received more and more attention due to the functional groups on their surface, hydrophobic cavity and adjustable sizes. Thus, dendrimers have been widely used in many fields. Peptide dendrimer is a sort of dendritic polymer, which contains peptide bonds in the structure. Owing to the globular structure similar to the protein, excellent water solubility, biocompatibility, biodegradability and low toxicity, peptide dendrimer could be used as drug delivery carrier. In addition, hydrophobic cavity can be used to solubilize hydrophobic drugs, in which the drugs can be released slowly. The present review highlights the current status of synthesis of peptide dendrimers, and it also summarizes and forecasts the interaction mechanism between drug molecules and peptide dendrimers, and the application of peptide dendrimers in drug delivery system.

Key words: polymer material, peptide dendrimers, globular structure, drug delivery, carrier

Cite this article

Zhang Shaofei, Yang Jiandong, Liu Mingzhu, Lü Shaoyu, Gao Chunmei, Wu Can, Zhu Zhaoyan. Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System[J]. Acta Chim. Sinica, 2016, 74(5): 401-409.

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肽类树状大分子的合成及其在药物传输系统中的应用

Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System

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