合成双吲哚甲烷类衍生物的研究进展

doi:10.6023/cjoc1110263

摘要/Abstract

双吲哚甲烷类衍生物具有丰富的生物活性和药理活性, 在医药领域得到了广泛的应用. 近年来, 对双吲哚甲烷类衍生物的合成研究引起了人们的热点关注. 对双吲哚甲烷类衍生物的合成方法进行了综述, 并将催化剂按照不同的类型分为: (1)路易斯酸催化剂, (2)分子碘催化剂, (3)质子酸催化剂, (4)固载催化剂, (5)杂多酸催化剂, (6)有机小分子催化剂, (7)配合物催化剂, (8)离子液体催化剂, (9)其它类型的催化剂.

关键词: 双吲哚甲烷衍生物, 合成, 催化剂, 研究进展

Bis(indolyl)methane derivatives are well known to possess various biological activities, pharmacological activities and have applications in pharmaceuticals. Recently, there is an increasing interest in the synthesis of bis(indolyl)alkanes. The paper makes a summary to the synthesis of bis(indolyl)methane derivatives in term of the kinds of the catalysts on the following: (1) Lewis acid catalyst, (2) molecular iodine catalyst (3) protoic acid catalyst, (4) solid-borne catalyst, (5) heterpoly acid catalyst, (6) small molecular organic catalyst, (7) coordination compound catalyst, (8) ionic liguid catalyst, (3) other catalysts.

Key words: bis(indolyl)methanes, synthesis, catalyst, research progress

引用此文

宫海伟, 解正峰. 合成双吲哚甲烷类衍生物的研究进展[J]. 有机化学, 2012, 32(07): 1195-1207.

Gong Haiwei, Xie Zhengfeng. Research Progress of Synthesis of Bis(indolyl)methanes[J]. Chin. J. Org. Chem., 2012, 32(07): 1195-1207.

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