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有机化学
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有机化学 ›› 2012, Vol. 32 ›› Issue (11): 2166-2170.DOI: 10.6023/cjoc201206009 上一篇    下一篇

研究简报

聚乙二醇-聚乳酸-聚甲基丙烯酸羟乙酯两亲性三嵌段聚合物的合成及其自组装研究

席陈彬a, 杨东a, 李静b, 晏建军b, 胡建华a   

  1. a 复旦大学高分子科学系 聚合物分子工程国家重点实验室 上海 200433;
    b 第二军医大学东方肝胆外科医院肝外一科 上海 200438
  • 收稿日期:2012-06-09 修回日期:2012-07-09 发布日期:2012-07-17
  • 通讯作者: 晏建军, 胡建华 E-mail:rian1971@126.com; hujh@fudan.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 50873029, 51073042, 51103026)、上海科技创新行动计划(No. 11JC1400600)、上海市自然科学基金(No. 11ZR1403100)和高等学校博士学科点专项科研基金(No. 20110071120006)资助项目.

Synthesis and Self-assembly of Poly(ethylene oxide)-b- poly(lactic acid)-b-poly(2-hydroxyethyl methacrylate) Amphiphilic Triblock Copolymer

Xi Chenbina, Yang Donga, Li Jingb, Yan Jianjunb, Hu Jianhuaa   

  1. a State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433;
    b Department of Hepatic Surgery I, Secondary Military Medical University, Shanghai 200438
  • Received:2012-06-09 Revised:2012-07-09 Published:2012-07-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 50873029, 51073042, 51103026), the Shanghai Scientific and Technological Innovation Project (No. 11JC1400600), the Natural Science Foundation of Shanghai City (No. 11ZR1403100), and the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20110071120006).

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被引次数

22 | 4

具有生物相容性的两亲性嵌段共聚物在水中易形成胶束, 在医学诊断、体内药物缓释及药物靶向输送方面具有广阔的应用前景. 利用二嵌段聚合物聚乙二醇-聚乳酸(PEG-PLA)引发甲基丙烯酸羟乙酯的原子转移自由基聚合, 制备了两亲性三嵌段聚合物聚乙二醇-聚乳酸-聚甲基丙烯酸羟乙酯(PEG-PLA-PHEMA), 利用凝胶渗透色谱(GPC), 红外光谱(FT-IR), 1H NMR表征了其聚合物组成; 然后利用透析法制备了不同分子量的聚合物胶束, 动态光散射(DLS)和透射电镜(TEM)结果表明其形貌规整、尺寸均一, 而且胶束粒径在PEG和PLA链段长度不变的条件下, 随PHEMA链段的变长而增大. PHEMA链上大量羟基的存在为聚合物胶束的功能化改性提供了反应位点, 加上本身完全由具良好生物相容性的聚合物制备, 使其在可控药物释放方面具有很大的应用潜力.

关键词: 两亲性, 原子转移自由基聚合, 聚乳酸, 聚甲基丙烯酸羟乙酯, 胶束

Amphiphilic copolymers that can assemble into core-shell micelles in aqueous media have potential application as drug carriers for controlled-release. In this article an amphiphilic triblock copolymer poly(ethylene oxide)-block-poly(lactic acid)-block-poly(2-hydroxyethyl methacrylate) (PEG-b-PLA-b-PHEMA) was synthesized by ring-opening reaction and atom transfer radical polymerization. The polymers were characterized by 1H NMR, FT-IR and gel permeation chromatography. In aqueous solution, PEG-b-PLA-b-PHEMA can self-assemble into micelles. Characterized by DLS and TEM, micelles are found to be spherical with uniform size. Large numbers of hydroxyl groups on the PHEMA chain offer reaction sites for subsequent functional modification, which make it a promising platforms for drug delivery systems.

Key words: amphiphilic, ATRP, PLA, PHEMA, micelle