SIOC English
有机化学
高级检索

有机化学 ›› 2014, Vol. 34 ›› Issue (9): 1895-1899.DOI: 10.6023/cjoc201404009 上一篇    下一篇

研究简报

无催化剂条件下有效的四组分反应合成2,3-二氢噻吩衍生物

张金鹏b, 高亚年a, 陈明a, 姜灵a, 夏盛a, 荣良策a   

  1. a 江苏师范大学化学化工学院, 徐州 221116;
    b 徐州医学院公共卫生学院, 徐州 221004
  • 收稿日期:2014-04-03 修回日期:2014-04-29 发布日期:2014-05-07
  • 通讯作者: 荣良策 E-mail:lcrong@jsnu.edu.cn; lcrong2005@yahoo.com
  • 基金资助:

    国家自然科学基础研究基金(No. 21172188)和江苏省功能性材料绿色合成重点实验室开放课题(No. K201312)资助项目.

An Efficient Synthesis of 2,3-Dihydrothiophene Derivatives from Four-Component Reactions under Catalyst-Free Conditions

Zhang Jinpengb, Gao Yaniana, Chen Minga, Jiang Linga, Xia Shenga, Rong Liangcea   

  1. a School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116;
    b Department of Public Health, Xuzhou Medical College, Xuzhou 221004
  • Received:2014-04-03 Revised:2014-04-29 Published:2014-05-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172188), and the Open Foundation of Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials (No. K201312).

PDF

970

被引次数

1

芳香醛、2，4-噻唑烷二酮、丙二腈和3-吡啶甲胺于95%乙醇中四组分反应，方便地获得一系列新的2，3-二氢噻吩衍生物. 这是杂环胺类化合物首次应用于噻吩衍生物的合成，具有反应条件温和、容易操作、产率高等优点. 产物的结构经过红外、核磁和高分辨质谱确定.

关键词: 噻吩, 2,4-噻唑烷二酮, 3-吡啶甲胺, 四组分反应

An efficient synthesis of 2,3-dihydrothiophene derivatives by the four-component reactions of aromatic aldehydes, thiazolidine-2,4-dione, malononitrile and pyridin-3-ylmethanamine has been reported. This reaction could be carried out smoothly without using any other catalysts in ethanol (95%) and the aromatic heterocyclic amine (pyridin-3-ylmethanamine) was first used for the synthesis of 2,3-dihydrothiophene derivatives. The advantages of this procure were mild reaction conditions, easy operation, and high yields. The products were identified by IR, 1H NMR and HRMS.

Key words: thiophene, thiazolidine-2,4-dione, pyridin-3-ylmethanamine, four-component reactions