Ugi反应脱Boc保护基环合策略在含氮杂环合成中的应用

doi:10.6023/cjoc201511004

摘要/Abstract

Ugi反应脱Boc保护基环合(UDC)策略是一种“三步一锅煮法”, 采用带Boc保护氨基的双官能团底物参与Ugi多组分反应, 随后在酸性条件下脱去保护基并环合得到含氮杂环化合物. 该策略具有快速、高效、经济和结构多样性的特点, 可用于构建复杂含氮杂环化合物库, 近来受到广泛关注. 对近年来UDC策略在合成五元、六元、七元杂环和天然产物方面应用的研究进展进行了综述.

关键词: UDC, Ugi反应, 脱Boc-保护基, 环合反应, 含氮杂环, 合成, 多组分反应

Ugi/de-Boc/cyclization (UDC) strategy represents a “three-step, one-pot procedure”, employing the Ugi multi-component reaction utilizing one bi-functional group substrates with N-Boc-protected amino, followed by Boc-deprotection and cyclization to synthesize nitrogen-containing heterocycles. This strategy has the characteristics of rapid, efficiency, economy and structural diversity, which can be used to build libraries of complex nitrogen-containing heterocycles and has drawn much attention recently. In this paper, the research progress of UDC strategy in the synthesis of five-, six- and seven-mem- bered heterocycles and natural products were summarized.

Key words: UDC, Ugi reaction, de-Boc group, cyclization, nitrogen-containing heterocycle, synthesis, multi-component reaction

引用此文

张钊瑞, 郑晓霖, 郭长彬. Ugi反应脱Boc保护基环合策略在含氮杂环合成中的应用[J]. 有机化学, 2016, 36(6): 1241-1265.

Zhang Zhaorui, Zheng Xiaolin, Guo Changbin. Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles[J]. Chin. J. Org. Chem., 2016, 36(6): 1241-1265.

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