有机化学 ›› 2016, Vol. 36 ›› Issue (5): 1028-1033.DOI: 10.6023/cjoc201511041 上一篇    下一篇

研究论文

二乙酸碘苯促进芳基酮烯醇硅醚的氯化反应

陈小伟, 种思颖, 杜刚刚, 黄丹凤, 王克虎, 苏瀛鹏, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2015-11-19 修回日期:2015-12-30 发布日期:2016-02-01
  • 通讯作者: 苏瀛鹏, 胡雨来 E-mail:suyp51@nwnu.edu.cn;huyl@nwnu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21362033,21502154)资助项目.

Diacetoxyiodobenzene Promoted Chlorination of Silyl Enol Ether of Aryl Ketones

Chen Xiaowei, Chong Siying, Du Ganggang, Huang Danfeng, Wang Kehu, Su Yingpeng, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2015-11-19 Revised:2015-12-30 Published:2016-02-01
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21362033, 21502154).

利用三甲基氯硅烷作为氯源,在二乙酸碘苯促进下,以芳基酮衍生的烯醇硅醚作为底物,合成了一系列α-氯代芳基酮.该方法反应条件温和,以中等至较好收率得到氯代芳基酮.若使用三甲基溴硅烷作为溴源,该方法还能用来制备α-溴代芳基酮.

关键词: α-氯代, 二乙酸碘苯, 烯醇硅醚, 芳基酮, α-溴代芳基酮

A series of α-chloroketones were obtained from silyl enol ethers of aryl ketones using trimethylchlorosilane as chlorine source and diacetoxyiodobenzene as promoter. The reaction occurs under mild condition yielding the product in moderate to good yields, and has the potential possibility for the synthesis of α-bromoketone by using trimethyl bromosilane as bromine source.

Key words: α-chlorination, diacetoxyiodobenzene, silyl enol ether, aryl ketone, α-bromoaryl ketone