具有优良抗癌活性的天然产物Neopeltolide的合成研究进展

doi:10.6023/cjoc201703017

摘要/Abstract

（+）-Neopeltolide是Wright小组从海洋的neopeltidae类深水海绵中分离得到了大环内酯化合物.该分子具有非常新颖的结构特征和非常优良的抗癌活性，到目前为止已经有二十多篇关于neopeltolide的合成论文报道，包括全合成和大环内酯骨架的合成.根据neopeltolide的合成策略的差异进行了简要的综述，主要分为全合成、大环内酯骨架合成、neopeltolide类似物合成等几个方面.

关键词: (+)-Neopeltolide, 大环内酯, 抗癌, 大环内酯化反应, Prins环化反应, 烯烃复分解反应

(+)-Neopeltolide was isolated from a deep-water sponge of the family neopeltidae. Due to its attractive novel structure and highly potent anticancer activity, more than twenty total and formal syntheses have been reported in last decade. Herein, the synthetic studies toward the total and formal syntheses of neopeltolide are reviewed according to the synthetic strategies toward the macrolactone core.

Key words: (+)-neopeltolide, macrolactone, anti-cancer, macrolactonization, prins cyclization, olefin metathesis

引用此文

于江帆, 冯若昆, 杨震. 具有优良抗癌活性的天然产物Neopeltolide的合成研究进展[J]. 有机化学, 2017, 37(10): 2526-2543.

Yu Jiangfan, Feng Ruokun, Yang Zhen. Synthetic Studies toward Neopeltolide:A Potent Anti-cancer Natural Product[J]. Chin. J. Org. Chem., 2017, 37(10): 2526-2543.

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