有机化学 ›› 2018, Vol. 38 ›› Issue (7): 1817-1822.DOI: 10.6023/cjoc201801030 上一篇    下一篇

研究简报

Pd/O2体系中邻炔基苯乙烯类衍生物的氯钯化/Heck串联反应研究

邱会华, 成博睿, 黄颖思, 陈翠, 周鹏   

  1. 广东石油化工学院化学工程学院 茂名 525000
  • 收稿日期:2018-01-23 修回日期:2018-03-26 发布日期:2018-04-12
  • 通讯作者: 邱会华 E-mail:qh198511@163.com
  • 基金资助:

    国家自然科学基金(No.21602035)和广东省自然科学基金(No.2016A030307030)资助项目.

Research on the Tandem Reaction via Chloropalladation/Heck Cross Coupling of o-(Alkynyl)styrenes with Pd/O2

Qiu Huihua, Cheng Borui, Huang Yingsi, Chen Cui, Zhou Peng   

  1. School of Chemical Engineering, Guangdong University of Petrochemical Technology, Maoming 525000
  • Received:2018-01-23 Revised:2018-03-26 Published:2018-04-12
  • Contact: 10.6023/cjoc201801030 E-mail:qh198511@163.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21602035) and the Natural Science Foundation of Guangdong Province (No. 2016A030307030).

在Pd/O2体系中,邻炔基苯乙烯类衍生物经过氯钯化/Heck偶联多步串联反应,获得了13个3位氯取代茚类化合物.该方法以氧气为唯一氧化剂,以氯化锂为氯源,避免了过量氯化铜的加入,具有绿色环保、条件温和、产率高和底物普适性较好等特点.

关键词: 钯催化, 氧气, 氯钯化,

An economic and environmental synthestic method for 3-chloroindenes from o-(alkynyl)styrenes through tandem reactions including choropalladation/Heck cross coupling in Pd/O2 system was reported. Taking green dioxygen as sole oxidant and LiCl as chlorine source, 13 functionalized 3-chloroindenes could be synthesized in moderate to high yield without the addition of CuCl2

Key words: Pd-catalyzed, dioxygen, chloropalladation, indene