α,α-二氟-β-氨基膦酸酯的合成与应用研究进展

doi:10.6023/cjoc202405013

摘要/Abstract

α,α-二氟-β-氨基膦酸酯因其含有一个氨基基团,可以作为氨基酸的类似物,在生物化学领域引起了广泛的研究兴趣。更重要的是,这类化合物还是非常高效的有机合成中间体,其在二氟膦酸酯衍生物的合成方面有非常重要的应用。因此,α,α-二氟-β-氨基膦酸酯的合成和应用是磷化学领域的研究热点。在这篇综述文章中,我们较为系统全面的总结了近些年有关α,α-二氟-β-氨基膦酸酯的研究进展,讨论了α,α-二氟-β-氨基膦酸酯的合成,及其相关的反应,为二氟膦酸酯衍生物的合成研究提供了一定的参考。

关键词: 二氟甲基膦酸酯, α,α-二氟-β-氨基膦酸酯, 卡宾, 重氮, 胺, 生物活性化合物

α,α-Difluoro-β-aminophosphonates can be looked as structural analogies with α-amino acids, which have attracted great attention in biological and medicinal chemistry during the past decades. Furthermore, these compounds also belong to an important type of organic building blocks for the rapid synthesis of difluoromethylenephosphonate-containing molecules. Thus, the preparation and application of α,α-difluoro-β-aminophosphonates are hot research topics in organic phosphine chemistry. This review presents a comprehensive summary of the literature reports related to α,α-difluoro-β-aminophosphonates in recent years. Aspects of synthesis and applications of α,α-difluoro-β-aminophosphonates are discussed. This review article will provide critical guidance for the further development of reactions and applications for the synthesis of difluoromethylenephosphonate derivatives.

Key words: aminophosphonates, α,α-difluoro-β-aminophosphonates, carbene, diazo compounds, amine

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杜友龙, 王倩, 梅海波, RomanaPajkert, Gerd-VolkerRöschenthaler, 韩建林. α,α-二氟-β-氨基膦酸酯的合成与应用研究进展[J]. 有机化学, doi: 10.6023/cjoc202405013.

Youlong Du, Qian Wang, Haibo Mei, Romana Pajkert, Gerd-Volker Röschenthaler, Jianlin Han. Recent Advances on the Synthesis and Application of α,α-Difluoro-β-aminophosphonates[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202405013.

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