有机膦催化合成中环化合物的研究进展

doi:10.6023/cjoc202405021

摘要/Abstract

中环（7-11元环）是一类重要的有机分子骨架,广泛存在于药物、农药以及许多具有生物活性的天然产物中,在有机合成化学中占有重要地位。有机小分子催化反应是合成中环化合物的重要方法之一,其中,有机膦催化具有成本低廉、环境友好以及催化剂易于回收利用等优点,为中环化合物的合成提供了一条经济而高效的途径。因此,近几十年来,该研究领域受到了持续而广泛的关注。本篇综述将对有机膦催化合成中环化合物的研究进展进行总结,详细阐述不同反应底物类型、反应机理等。

关键词: 有机催化, 膦催化剂, 环化反应, 中环化合物

Medium-sized rings (7-11 membered ring) are a class of important skeleton in organic molecules, which are commonly found in drugs, pesticides and many biologically active natural products, and play essential roles in organic synthetic chemistry. Organo-catalysis is an important methodology for the synthesis of medium-sized ring compounds, among which, organophosphine catalysis has the advantages of low cost, environmental friendliness, and easy recycling, which provides an economical and efficient route for the synthesis of medium-sized ring compounds. Therefore, this field of research has received continuous and extensive attention in recent decades. In this review, we will summarize the research progress on the organophosphine-catalyzed synthesis of medium-sized ring compounds, detailing the different types of reaction substrates, reaction mechanisms, etc.

Key words: Organocatalysis, Phosphine catalysts, Annulation reaction, Medium-sized ring compounds

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潘旭玲, 黄有. 有机膦催化合成中环化合物的研究进展[J]. 有机化学, doi: 10.6023/cjoc202405021.

Pan Xuling, Huang You. Progress in Synthesis of Medium-Sized Ring Compounds Catalyzed by Organophosphine[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202405021.

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