烯烃立体选择性卤胺化的研究进展

doi:10.6023/cjoc202505019

摘要/Abstract

烯烃与胺基和卤素基的区域选择性和立体选择性相邻双官能化可以通过催化卤化方法有效地完成. 立体选择性卤胺化反应已成为将卤素官能团引入手性胺的重要方法, 在药物化学和有机合成中得到了广泛应用. 过去几十年来, 在催化系统和方法创新的推动下, 这一领域取得了重大进展. 使用手性催化剂对官能化和非官能化烯烃进行烯烃立体选择性卤胺化已成为一个突出的研究领域. 本文全面概述了过去几十年来立体选择性卤胺化领域取得的重大进展. 文章探讨了催化剂设计方面的创新, 这些创新促进了更高效、更具选择性的转化. 文章还分析了反应条件的优化, 这对提高这些反应的整体性能和适用性至关重要. 此外, 本文还对立体选择性卤胺化的未来进行了展望.

关键词: 分子间, 分子内, 立体选择性卤胺化, 催化, 烯烃

The regioselective and stereoselective vicinal difunctionalization of alkenes with amino and halogen groups can be efficiently achieved through catalytic halogenation methods. Stereoselective haloamination reactions have emerged as an important strategy for introducing halogen functionalities into chiral amines, finding widespread applications in pharmaceutical chemistry and organic synthesis. Over the past few decades, significant progress has been made in this field, driven by innovations in catalytic systems and methodologies. The stereoselective haloamination of both functionalized and non-functionalized alkenes using chiral catalysts has become a prominent area of research. This article provides a comprehensive overview of the major advances in stereoselective haloamination achieved in recent decades. It explores innovations in catalyst design that have facilitated more efficient and selective transformations. The optimization of reaction conditions is also analyzed, as it plays a crucial role in enhancing the overall performance and applicability of these reactions. Furthermore, the article offers perspectives on the future of stereoselective haloamination.

Key words: Intermolecular, Intramolecular, Stereoselective haloamination, Catalysis, Olefins

引用此文

钟国, 白萌冉, 崔斌, 孙慧. 烯烃立体选择性卤胺化的研究进展[J]. 有机化学, doi: 10.6023/cjoc202505019.

Zhong Guo, Bai Mengran, Cui Bin, Sun Hui. Advances in Stereoselective Haloamination of Alkenes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202505019.

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