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有机化学
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有机化学 ›› 1987, Vol. 7 ›› Issue (3): 196-198. 上一篇    下一篇

研究论文

氧化苯乙烯和氧化二苯乙烯的区域选择性和立体选择性开环

韩广甸;郑盛基   

  1. 中国医学科学院药物研究所;美国德克萨斯州农工大学化学系
  • 发布日期:1987-06-25

Regioo and stereoselective cleavage of styrene and stilbene oxides

HAN GUANGDIAN;ZHENG SHENGJI   

  • Published:1987-06-25

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643

本文报道NaBH4-CoCl2可使氧化苯乙烯类化合物发生区域选择性开环,主要生成β-苯乙醇生物对于氧化二苯乙烯类化合物,由于受到苯环的空间阻碍,使其开环能力减弱,如反式氧化二苯乙烯比顺式异构体更难于开环.

关键词: 钠化合物, 钴化合物, 氯化物, 选择性, 区域, 开环反应, 立体选择性, 环氧化物, 硼烷类, 苯乙烯 P, 还原剂, 二苯代乙烯 P

The oxirane ring of styrene oxides was found to be regioselectively cleaved with NaBH4 and CoCl2 to afford phenethyl alcs. Furthermore, the oxirane ring of trans-stilbene oxide was more difficult to cleave than that of the cis-isomer owing to the steric effect of the benzene ring from both sides.

Key words: SODIUM COMPOUNDS, COBALT COMPOUNDS, CHLORIDE, SELECTIVITY, REGION, RING CLEAVAGE REACTION, STEREOSELECTIVITY, EPOXIDE, BORANES, STYRENE P, REDUCER, DIPHENYLETHYLENE P

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