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有机化学
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有机化学 ›› 1991, Vol. 11 ›› Issue (2): 191-195. 上一篇    下一篇

研究论文

2-芳基-4-氧-4H-吡喃酮[3,2-c]-9-溴喹啉类化合物的合成

刘俊义;黄洁;蔡孟深   

  1. 北京医科大学药学院
  • 发布日期:1991-04-25

Synthesis of 2-aryl-4-oxo-4H-pyrano[3,2-c]-9-bromoquinolines

LIU ZHUNYI;HUANG JIE;CAI MENGSHEN   

  • Published:1991-04-25

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本文以3-乙醛基-4-羟基-6-溴喹啉为原料, 经与芳香醛缩合得查尔酮类化合物, 而后环合, 氧化生成2-芳基-4-氧-4H吡喃酮[3,3,-c]-9-溴喹啉类化合物。本文合成了七个查尔酮类化合物和七个氮杂黄酮类化合物。

关键词: 苯甲醛 P, 查耳酮 P, 乙醛 P, 黄酮类化合物, 溴化合物, 溴化物, 苯 P, 喹啉 P, 吡喃酮 P, 喹啉 P

Title compounds I (R = H, Cl; R1 = H, Cl, OH, MeO; R1 = H, OH, NO2) were synthesized from chalcones II with I2-DMSO-H2SO4. The chalcones were first heated at 100~120?for about 10 min. in DMSO in the presence of H2SO4 and then the reaction mixture was further heated in the presence of a small amount of iodine to give 50~85% yields of compounds I.

Key words: FLAVONOID, BENZALDEHYDE P, BROMINE COMPOUNDS, CHALCONE P, ACETALDEHYDE P, BROMIDE, PYRANONE P, BENZENE P, QUINOLINE P, QUINOLINE P

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