关键词: 半乳糖, 山东省自然科学基金, 氟脲嘧啶, 糖苷, 抗癌药, 相转移催化, 吡喃糖

Two acetyl galactopyranosides 2-O-benzyl-4-O-(2',3',4',6'-tetra-O-acetyl-b-D-galactopyranosyl)-5-fluoro uracil (I) and 2-O-benzyl-3-N-(2',3',4',6'-tetra-O-acetyl-b-D-galactopyranosyl)-5-fluoro uracil (II) were synthesized by the reaction of 2-O-benzyl-5-fluorouracil and a-acetobromogalactose (III). Under phase transfer catalysis I was also synthesized by the reaction of silver salt of 2-O-benzyl-5-fluorouracil and III. I and II were treated with ammonia in MeOH to obtain deacetylated galactopyranosides, which were hydrogenated in the presence of 10% Pd-C catalyst to obtain galactopyranosides of 5-fluorouracil, IV and V resp.

Key words: FLUOROURACILUM, ANTICARCINOGEN, GALACTOSE, PYRANOSE, GLYCOSIDE, PHASE TRANSFER CATALYSIS