有机化学 ›› 1996, Vol. 16 ›› Issue (3): 218-222. 上一篇    下一篇

研究论文

间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮的Mannich反应

邹君华   

  1. 西南师范大学化学化工学院
  • 发布日期:1996-06-25

The Mannich reaction between 3-nitrobenzaldehyde (3-chlorobenzaldehyde), aromatic amines and aromatic ketones

ZOU JUNHUA   

  • Published:1996-06-25

间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮在20~25℃和催化量的浓盐酸催化下能直接进行Mannich反应, 用一步合成法合成15个1-芳基-3-芳胺基(3-硝基苯基)丙酮。产率为68~87%。产物结构经元素分析, IR, ^1H NMR, MS鉴定。本文还讨论了反应的适宜条件。

关键词: 芳香酮, 间硝基苯甲醛, 红外分光光度法, 盐酸, 间氯苯甲醛, 芳香胺, 质子磁共振谱法, 曼尼希反应

In the presence of catalytic amount of hydrochloric acid, the Mannich reaction of 3-nitrobenzaldehyde (3-Chlorobenzaldehyde), aromatic amines and aromatic ketones can take place directly at 20~25℃. Fifteen corresponding Mannich bases (1a~1o), 1-aryl-3- arylamino [3-nitro(chloro) phenyl] acetone, were prepared with 68~87% yield. Some compounds were verified by elemental analysis, IR, ^1H NMR, MS. The reaction conditions were also discussed in this paper.

Key words: HYDROCHLORIC ACID, PROTON MAGNETIC RESONANCE SPECTROMETRY, AROMATIC AMINE, MANNICH REACTION, INFRARED SPECTROPHOTOMETRY

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