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有机化学
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有机化学 ›› 1999, Vol. 19 ›› Issue (1): 59-62. 上一篇    下一篇

研究论文

用(R)-(+)-缩水甘油的亲核开环反应制备手性连二醇

张生勇;戴寿荣;孙晓莉;王建华   

  1. 第四军医大学化学教研室.;西北大学化学系.西安(710069)
  • 发布日期:1999-02-25

Synthesis of chiral nonracemic vicinal diols via nucleophilic ring- opening of (R)-(+)-glycidol

Zhang Shengyong;Dai Shourong;Sun Xiaoli;Wang Jianhua   

  1. Univ of No.4 Military Medicine, Teach Lab of Chem.;Northwest Univ, Dept Chem.Xian(710069)
  • Published:1999-02-25

以D-甘露醇为原料合成(R)-(+)-缩水甘油1。该环氧化合物的亲核开环反应为高立体选择性地(93%-96%e.e.)制备各种手性连二醇提供了一条简便途径。

关键词: 亲核反应, 开环反应, 二元醇, 选择性, 甘露醇, 缩水甘油

(R)-(+)-Glycidol 1 was synthesized from D-mannitol. Nucleophilic ring-opening of this epoxide gave a convenient method for generation a variety of chiral nonracemic vicinal diols in high stereoselectivity (93%-96% e.e.).

Key words: NUCLEOPHILIC REACTION, SELECTIVITY, MANNITOL, RING CLEAVAGE REACTION, DIHYDRIC ALCOHOL, EPIHYDRIC ALOCOHOL (=EPIHYDRIN ALCOHOL)

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