有机化学 ›› 1999, Vol. 19 ›› Issue (3): 271-277. 上一篇    下一篇

研究论文

吡咯烷类手性二胺配体N-烷基化物的简易合成法

刘志煜;杨家德   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:1999-06-25

A facile synthesis of (S^2-[(N-alkylated pyrrolidin-1-ylmethyl]- pyrrolidine and related chiral diamine ligands

Liu Zhiyu;Yang Jiade   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:1999-06-25

吡咯烷类及有关的手性二胺配体通过使用氯化锌-多聚甲醛-硼氢化钾或硼氢化钠一锅煮反应进行烷基化,具有产率高、操作简易等优点。

关键词: 手性, 手性配体, 吡咯烷, 合成法, 烷基化, 二胺

The title ligands are easily synthesized by reductive amination of the corresponding aldehydes with (S)-(+)-2-(1-pyrrolidino) methyl- pyrrolidine and related amines using zinc chloride and potassium borohydride or sodium borohydride in dichloromethane at room temperature.

Key words: ALKYLATION, PYRROLIDINE, DIAMINE, CHIRALITY, SYNTHESIS METHODS

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