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有机化学
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有机化学 ›› 1999, Vol. 19 ›› Issue (3): 288-292. 上一篇    下一篇

研究论文

3, 6-二芳基-5, 6-二氢均三唑[3, 4-b][1, 3, 4]噻二唑的合成 及生物活性

王忠义;尤田耙;尤凌峰   

  1. 中国科学技术大学化学系.合肥(230026)
  • 发布日期:1999-06-25

Syntheses and antibacterial activity of 3, 6-diaryl-5, 6-dihydro-s- triazolo[3, 4-b][1, 3, 4] thiadiazole

Wang Zhongyi;You Tianpa;You Lingfeng   

  1. Univ Sci & Technol China, Dept Chem.Hefei(230026)
  • Published:1999-06-25

被引次数

34

研究了在L-(+)-酒石酸存在下3-芳基-4-氨基-5-巯基-1,2,4-均三唑与醛的Mannich反应及分子内的加成反应,合成了15个新的手性稠杂环化合物3,6-二芳基-5,6-二氢均三唑[3,4-b][1,3,4]噻二唑,利用IR、^1HNMR和MS确证了其结构,并测试了部分化合物的生物活性。

关键词: 三唑, 加成反应, 二芳基, 酒石酸, NMR, 稠杂环化合物, 二氢, 生物活性, 合成, 噻二唑

Fifteen new chiral 3, 6-diaryl-5, 6-dihydro-s-triazolo[3, 4-b][1, 3, 4] thiadiazoles have been synthesized by the Mannich reaction of 3- aryl-4-amino-5-mercapto-1, 2, 4-triazole with various aldehydes in the presence of catalytic amounts of L-(+)-tartaric acid. Some compounds were found to have moderatel antibacterial activities.

Key words: TARTARIC ACID, SYNTHESIS, NMR, DIARYL GROUP, DIHYDRO, THIADIAZOLE, ADDITION REACTION, TRIAZOLE, BIOLOGICAL ACTIVITY

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