有机化学 ›› 1999, Vol. 19 ›› Issue (4): 364-372. 上一篇    下一篇

研究论文

D-奎尼酸: 一个多用途的手性合成子

黄培强   

  1. 厦门大学化学系.厦门(361005)
  • 发布日期:1999-08-25

D-quinic acid, a versatile chiron in organic synthesis

Huang Peiqiang   

  1. Xiamen Univ, Dept Chem.Xiamen(361005)
  • Published:1999-08-25

综述了D-奎尼酸在各种环状和链状生物活性化合物合成中的应用。奎尼酸分子中特有的顺式γ-羟基羧酸的结构单元提供了区别分子中各种羟基,以及进行其它区域选择性和立体选择性控制的方便途径。奎尼酸的结构特征以及其价廉、易得的优点,使之成为一个有用的而且重要的手性合成子。

关键词: 生物活性化合物, 手性分子, 奎尼酸, 合成

This review describes the use of D-Quinic acid in the synthesis of various natural or un-natural bioactive compounds. Because of the presence of cis-γ -hydroxyl-carboxyl subunit in quinic acid, a lactone ring can be formed easily. The thus formed rigid system provides good control elements for many regio- and stereoselective transformations. Besides, D-quinic acid is also readily available. These make this compound a useful and versatile chiron for both cyclic (hexanoids and pentanoids) and acyclic bioactive compounds.

Key words: SYNTHESIS

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