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有机化学
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有机化学 ›› 2000, Vol. 20 ›› Issue (3): 344-347. 上一篇    下一篇

研究论文

手性-3, 5-二取代-1', 2', 4'-三唑-[3', 4'-b]-2, 4-二氢间 噻二嗪的合成及 生物活性

史好新;王忠义;史海健   

  1. 安徽师范大学化学系.合肥(241000)
  • 发布日期:2000-06-25

Synthesis and the biological activity of chiral 3, 5-disubstituted S- triazolo[3, 4-b]-2, 4-dihydrogen-1, 3, 5-thiadiazines

Shi Haoxin;Wang Zhongyi;Shi Haijian   

  1. Anhui Normal Univ.Hefei(241000)
  • Published:2000-06-25

PDF

496

被引次数

13

以3-芳基-5-巯基-1,2,4-均三唑为原料,和甲醛及S-(-)-α-苯乙胺在酸催化作用下合成了6种新的化合物。研究了合成反应的条件。通过元素分析、IR、^1HNMR、和MS确证了其结构,测定了比旋光度和生物活性。结果表明,一些化合物具有一定的抗菌活性。

关键词: 芳基, 巯基, 三唑P, 结构分析, 噻二嗪P, 生物活性, 曼尼希反应, 手征性

Six Novel compounds were synthesized by the reaction of 3-aryl-5- mercapto-1, 2, 4-S-triazoles with formaldehyde and S-(-)-α- phenylethylamine in the presence of as acid catalyst. The reaction conditions were investigated. The structure of these compounds were established by elemental analysis, IR, ^1H NMR, MS and specificrotation. Some these compounds show that some compounds possess strong antibacterial activities.

Key words: ARYL GROUP, MERCAPTO GROUP, PYRRODIAZOLE P, STRUCTURAL ANALYSIS, THIADIAZINE P, BIOLOGICAL ACTIVITY, MANNICH REACTION, CHIRALITY

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