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有机化学
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有机化学 ›› 2000, Vol. 20 ›› Issue (4): 560-563. 上一篇    下一篇

研究论文

高碘酸盐氧化1,6-二-O-三苯甲基-D-甘露醇的区选性

赵凯元;王 清   

  1. 苏州铁道师范学院化学系
  • 发布日期:2000-08-25

Rigioselectivity of periodate oxidation of 1,6-bis-O- (triphenylmethyl)-D-mannitol

Zhao Kaiyuan;Wang   

  • Published:2000-08-25

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合成了模型化合物1,6-二-O-三苯甲基-D-甘露醇(TPMM)，研究了它在混合溶剂中的高碘酸盐氧化反应的区选性。对氧化产物进行了分离鉴定。取得了最终氧化产物α-O-三苯甲基乙醛，制得了重要有机合成原料α-羟基乙醛。

关键词: 高碘酸盐, 氧化, 甘露醇P, 选择性

A model compound 1,6-bis-O-(triphenylmethyl)-D-mannitol(TPMM) is synthesized, and the regioselectivity of periodate oxidation reaction of TPMM in mixed solvents is studied. The oxidation products are separated and analyzed. The main oxide product, α-O- (triphenylmethyl)-acetaldehyde(TPMA), and α-hydroxyl acetaldehyde, prepared from TPMA, are important organic synthetic intermediate.

Key words: PERIODATE, OXIDATION, MANNITOL P, SELECTIVITY

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