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有机化学
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有机化学 ›› 2002, Vol. 22 ›› Issue (1): 71-73. 上一篇    

研究论文

室温离子液体催化“一锅法”合成3, 4-二氢嘧啶-2-酮

彭家建;邓友全   

  1. 中国科学院兰州化学物理研究所.兰州(730000);羰基合成与选择氧化国家重点 实验室;中国科学院生态与绿色环境研究中心
  • 发布日期:2002-01-25

Ionic liquids catalyzed one-pot synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones

Peng Jiajian;Deng Youquan   

  1. Lanzhou Inst Chem Phys, CAS.Lanzhou(730000)
  • Published:2002-01-25

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利用室温离子液体作催化剂，芳香醛、尿素和乙酰乙酯或乙酰丙酮三组分缩合制备3,4-二氢嘧啶-2-酮衍生物，反应条件温和，反应时间短，且不需另加有机溶剂，考察了不同取代基对芳香醛、尿素和乙酰乙酸乙酯或乙酰丙酮三组分缩合反应的影响。还考察了不同的室温离子液体的催化性能，发现1-丁基-3-甲基咪唑六氟磷酸盐较1-丁基-3-甲基咪唑四氟硼酸盐的催化效果略好。

关键词: 离子液体, 咪唑P, 氟磷酸盐, 氟硼酸盐, 一锅法, 催化剂, 缩合反应, 合成法, 二氢嘧啶酮, 嘧啶酮P

Dihydropyrimidinones and their derivatives were synthesised in high yields by a one-pot threecomponent Biginelli condensation in th epresence of catalytic amounts of room temperature ionic liquids such as 1-n-Butyl- 3-methylimidazolium tetrafluoroborate (BMImBF4) and hexafluorophosphorate (BMImPF6) under neurtral and solvent-free conditions. The one-pot Biginelli condensation has such advantages as high-yields, short reaction time, and simple procedure.

Key words: IMIDAZOLE P, FLUOROBORATE, CATALYST, CONDENSATION REACTION, SYNTHESIS METHODS, PYRIMIDONE P

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