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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (10): 1304-1306. 上一篇    下一篇

研究简报

新多取代吡啶类化合物的合成及生物活性

钟滨, 李正名*, 刘长令, 赵卫光   

  1. 南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2004-01-12 修回日期:2004-04-08 接受日期:2004-05-12 发布日期:2022-09-20
  • 基金资助:
    国家973 (No. 2003CB114406)资助项目.

Synthesis and Biological Activity of Polysubstituted Pyridines

ZHONG Bin, LI Zheng-Ming*, LIU Chang-Ling, ZHAO Wei-Guang   

  1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:2004-01-12 Revised:2004-04-08 Accepted:2004-05-12 Published:2022-09-20
  • Contact: * E-mail: zml@nankai.edu.cn

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为寻找具有农用生物活性的新颖化合物,以2-氰基硫代乙酰胺为起始原料经由三步反应,设计并合成出了一系列新颖的多取代吡啶衍生物2-甲基-5-氰基-6-炔丙硫基-4-(2-呋喃基或噻吩基)吡啶-3-甲酸甲酯或乙酯和6-甲基-5-乙酰基-2-炔丙硫基-4-(2-呋喃或噻吩基)吡啶-3-乙腈.所有新化合物均经过1H NMR和元素分析确证.初步生物活性测定表明:化合物7有一定的除草和杀菌活性.

关键词: 多取代吡啶, 合成, 生物活性

In an attempt to search for new compounds with agricultural bioactivity, a series of new polysubstituted pyridine derivatives, ethyl or methyl 5-cyano-4-(furan or thiophen-2-yl)-2-methyl-6-(prop-2-ynylthio)pyridine-3-car~boxylate and 5-acetyl-4-(furan or thiophen-2-yl)-6-methyl-2-(prop-2-ynylthio)pyridine-3-carbonitrile have been designed and synthesized by a three-step synthetic route. The structures of all the compounds prepared were confirmed by elemental analyses and 1H NMRspectra. The results of preliminary bioassay indicate that compounds 7 possess certain herbicidal and fungicidal activities.

Key words: polysubstituted pyridine, synthesis, biological activity