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有机化学 ›› 2004, Vol. 24 ›› Issue (8): 902-905. 上一篇    下一篇

研究论文

2-芳基-2-吗啉醇的合成

胡艾希*,a, 肖新荣a,b, 陈科a, 曹高a, 郭小华a   

  1. a湖南大学化学化工学院 长沙 410082
    b南华大学化学化工学院 衡阳 421001
  • 收稿日期:2003-09-11 修回日期:2004-02-20 接受日期:2004-02-20 发布日期:2022-09-20
  • 通讯作者: * E-mail: axhu@hnu.cn

Synthesis of 2-Aryl-2-morpholinol

HU Ai-Xi*,a, XIAO Xin-Ronga,b, CHEN Kea, CAO Gaoa, GUO Xiao-Huaa   

  1. aCollege of Chemistry and Chemical Engineering, Hunan University, Changsha 410082
    bCollege of Chemistry and Chemical Engineering, Nanhua University, Hengyang 421001
  • Received:2003-09-11 Revised:2004-02-20 Accepted:2004-02-20 Published:2022-09-20

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醇胺分别与2-溴-4'-甲氧基苯乙酮、2-溴-3'-氯苯丙酮、2-溴-4'-苄氧基苯基丙酮、2-溴-4'-苄氧基苯戊酮、6-甲氧基-2-溴乙酰基萘和6-甲氧基-2-(2-溴丙酰基)萘反应,合成相应的2-芳基-2-吗啉醇(产率80.7%～97.5%)及其盐酸盐.其结构经1H NMR, IR, MS确证.

关键词: 2-芳基-2-吗啉醇, 2-芳基-2-吗啉醇盐酸盐, 氨化, 合成

2-Aryl-2-morpholinols were synthesized via the reactions of aminoalcohol with 2-bromo-4'-methoxyacetophenone,2-bromo-4'-chloropropiophenone,2-bromo-4'-benzyloxypropiophenone,2-bromo-4'-benzyl~oxy~pento~phen~one, 6-methoxy-2-bromoacetylnaphthalene and6-methoxy-2-(2-bromopropionyl)naphthalene by divergent synthetic method withyields of 80.7%～97.5%, respectively. The structures of 2-aryl-2-morpholinols were confirmed by 1H NMR, IR and MS spectra.

Key words: 2-aryl-2-morpholinol, 2-aryl-2-morpholinol hydrochloride, amination, synthesis