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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (02): 204-207. 上一篇    下一篇

研究简报

哒嗪酮衍生物的合成和生物活性研究

李洪森，凌云，郭钰来，杨新玲*，陈馥衡   

  1. (中国农业大学应用化学系 北京 100094)
  • 收稿日期:2004-02-10 修回日期:2004-09-01 发布日期:2005-01-15
  • 通讯作者: 杨新玲

Study on the Synthesis and Bioactivity of Pyridazinone Derivatives

LI Hong-Sen,LING Yun,GUO Yu-Lai,YANG Xin-Ling*,CHEN Fu-Heng   

  1. (Department of Applied Chemistry, China Agricultural University, Beijing 100094)
  • Received:2004-02-10 Revised:2004-09-01 Published:2005-01-15
  • Contact: YANG Xin-Ling

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1966

被引次数

25

合成了16个含哒嗪酮环新化合物, 所有化合物结构均通过1H NMR, IR和元素分析确证. 生物活性初步研究结果表明, 在200 mg/kg浓度下, 化合物7a, 7b, 7c和7d对二龄家蝇幼虫具有较好的杀虫活性, 对三龄蝗蝻活性不明显.

关键词: 哒嗪酮, 合成, 生物活性

Sixteen compounds of pyridazinone derivatives were synthesized. Their structures were determined by 1H NMR, IR spectra and elemental analysis. In the preliminary bioassay test, compounds 7a, 7b, 7c and 7d showed good activity against second-instar housefly larvae and lower activity for third-instar nymphs of locusts at concentration of 200 mg/kg .

Key words: biological activity, synthesis, pyridazinone