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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (04): 466-469. 上一篇    下一篇

研究简报

{苯基-[(吡啶-4-羰基)-氨基]-甲基}-膦酸二烷基酯的合成与波谱表征

方华1，方美娟1，留筱厦1，许鹏翔1，赵玉芬*,a,b   

  1. (1厦门大学化学化工学院福建省化学生物学省重点实验室 厦门 361005)
    (2清华大学生命有机磷化学及化学生物学教育部重点实验室 北京 100084)
  • 收稿日期:2004-06-07 修回日期:2004-11-10 发布日期:2005-03-30
  • 通讯作者: 赵玉芬

Synthesis and Spectral Characterization of {Phenyl-[(pyridine-4-carbonyl)amino]methyl}phosphonic Acid Dialkyl Ester

FANG Hua1,FANG Mei-Juan1,LIU Xiao-Xia1,XU Peng-Xiang1
ZHAO Yu-Fen*,1,2   

  1. (1 Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xia-men University, Xiamen 361005)
    (2 Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of
    Chemistry, Tsinghua Univer-sity, Beijing 100084)
  • Received:2004-06-07 Revised:2004-11-10 Published:2005-03-30
  • Contact: ZHAO Yu-Fen

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1201

被引次数

13

α-氨基膦酸及其衍生物作为天然氨基酸的含磷类似物, 具有多种生物活性, 它的合成与性质的研究引起人们的浓厚兴趣. 合成了一系列含磷化合物, 产物经元素分析、红外光谱、核磁共振、质谱鉴定, 并初步研究这些化合物的抗菌与抗肿瘤生物活性.

关键词: α-氨基膦酸, 合成, 波谱表征, 生物活性

α-Aminophosphonic acids and their derivates, as phosphorous analogs of amino acid, have attracted much attention because they show wide biological activities. In this paper, the title compounds, {phenyl-[(pyridine-4-carbonyl)amino]methyl}phosphonic acid dialkyl esters, were synthesized via Mannich reaction and peptide coupling reaction. Their structures were confirmed by elemental analysis, IR, 1H NMR, 13C NMR and MS spectra, and the antibacterial and antitumor activities of these compounds were given in this paper.

Key words: spectral characterization, biological activ-ity, synthesis, α-aminophosphonic acid