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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (05): 587-590. 上一篇    下一篇

研究简报

4-甲基-苯磺酸-2-氧-2-[3-(5-芳基-[1,3,4]噁二唑-2-基)-硫脲]-乙基酯的合成及生物活性研究

李超，覃章兰*，李秀文，张欣   

  1. (华中师范大学化学学院 武汉 430079)
  • 收稿日期:2004-06-15 修回日期:2004-11-19 发布日期:2004-04-30
  • 通讯作者: 覃章兰

Synthesis and Biological Activities of Toluene-4-sulfonic Acid 2-Oxo-2-[3-(5-aryl-[1,3,4]oxadiazol-2-yl)thioureido]ethyl Esters

LI Cha,QIN Zhang-Lan*,LI Xiu-Wen,ZHANG Xin   

  1. (College of Chemistry, Central China Normal University, Wuhan 430079)
  • Received:2004-06-15 Revised:2004-11-19 Published:2004-04-30
  • Contact: QIN Zhang-Lan

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合成了12个未见文献报道的4-甲基-苯磺酸2-氧-2-[3-(5-芳基-[1,3,4]噁二唑-2-基)-硫脲]-乙基酯, 其结构经元素分析、1H NMR和IR确证. 初步活性测试结果表明: 部分化合物有较好的杀菌活性.

关键词: 4-甲基-苯磺酸-2-氧-2-[3-(5-芳基-[1,3,4]噁二唑-2-基)-硫脲]-乙基酯, 2-氨基-5-芳基-[1,3,4]噁二唑, 杀菌活性, 合成

Twelve new toluene-4-sulfonic acid 2-oxo-2-[3-(5-aryl-[1,3,4]oxadiazol-2-yl)thioureido]ethyl esters were synthesized. Their structures were determined by IR, 1H NMR spectra and elemental analysis. The preliminary biological activity tests show that some of these target compounds have good fungicidal ac-tivities.

Key words: fungicidal activity, 2-amino-5-aryl-[1,3,4]oxadiazole, synthesis, toluene-4-sulfonic acid 2-oxo-2-[3-(5-aryl-[1,3,4]oxadiazol-2-yl)thioureido]ethyl ester