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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (06): 679-683. 上一篇    下一篇

研究论文

新型酯键型鹅去氧胆酸分子钳的设计合成

赵志刚，张佩玉，杨祖幸，陈淑华*   

  1. (四川大学化学学院 成都 610064)
  • 收稿日期:2004-08-05 修回日期:2004-12-21 发布日期:2005-05-30
  • 通讯作者: 陈淑华

Design and Synthesis of Novel Ester-type Molecular Tweezers Derived from Chenodeoxycholic Acid

ZHAO Zhi-Gang, ZHANG Pei-Yu, YANG Zu-Xing, CHEN Shu-Hua*   

  1. (Faculty of Chemistry, Sichuan University, Chengdu 610064)
  • Received:2004-08-05 Revised:2004-12-21 Published:2005-05-30
  • Contact: CHEN Shu-Hua

PDF

1296

被引次数

46

以鹅去氧胆酸为隔离基、芳香族化合物为手臂设计合成了一类新型的分子钳, 其结构经1H NMR, IR, MS和元素分析确证, 并且考察了其对D/L-氨基酸甲酯的对映选择性识别性能. 初步的结果表明, 这类手性分子钳对D-氨基酸甲酯有较好的识别性能.

关键词: 鹅去氧胆酸, 分子钳, 合成

A novel type of chiral molecular tweezers has been designed and synthesized by using chenodeoxycholic acid as spacer and aromatic compounds as arm. Their structures were confirmed by 1H NMR, IR, MS spectra and elemental analysis. Their recognition properties for methyl esters of amino acids were investigated. The preliminary results indicate that these chiral molecular tweezers are favorable for complexation with D-amino acid methyl esters.

Key words: chenodeoxycholic acid, synthesis, molecular tweezer