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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (06): 724-726. 上一篇    下一篇

研究简报

4H-吡啶并[3,2-e][1,3]噻嗪-4-酮嘧啶衍生物的合成

孙晓红*,1，吉鹏举1，刘源发2，陈邦2，贾婴琦2   

  1. (1西北大学化学研究所 西安 710069)
    (2西北大学化学系 西安 710069)
  • 收稿日期:2004-07-01 修回日期:2004-12-10 发布日期:2005-05-30
  • 通讯作者: 孙晓红

Synthesis of 2-(Pyrimidin-2-yl)amino-4H-pyrido[3,2-e]-[1,3]thiazin-4-one Derivatives

SUN Xiao-Hong*1, JI Peng-Ju1LIU Yuan-Fa2, CHEN Bang2JIA Ying-Qi2   

  1. (1 Institute of Chemistry, Northwest University, Xi'an 710069)
    (2 Department of Chemistry, Northwest University, Xi'an 710069)
  • Received:2004-07-01 Revised:2004-12-10 Published:2005-05-30
  • Contact: SUN Xiao-Hong

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2-氯烟酸异硫氰酸酯在碱性介质中与取代2-氨基嘧啶反应直接得到4H-吡啶并[3,2-e][1,3]噻嗪-4-酮嘧啶. 所合成的6个未见文献报道的目标化合物经IR, 1H NMR和元素分析证实了其结构, 并对反应可能机理进行了探讨.

关键词: 异硫氰酸酯, 取代2-氨基嘧啶, 4H-吡啶并[3,2-e][1,3]噻嗪-4-酮嘧啶, 合成

2-Chloronicotioyl isothiocyanate reacted with substituted 2-aminopyrimidine under the alkali condition to give 2-(pyrimidin-2-yl)amino-4H-pyrido[3,2-e][1,3]thiazin-4-one directly. Six 2-(pyrimidin-2- yl)amino-4H-pyrido[3,2-e][1,3]thiazin-4-one compounds were synthesized. The structures of these compounds were confirmed by IR, 1H NMR spectra and elemental analyses. A possible mechanism of the reaction was proposed.

Key words: substituted 2-aminopyrimidine, 2-(pyrimidin-2-yl)amino-4H-pyrido-[3,2-e]- [1,3]thiazin-4-one, synthesis, isothiocyanate