有机化学 ›› 2005, Vol. 25 ›› Issue (07): 826-829. 上一篇    下一篇

研究论文

无溶剂条件下微波辐射合成2-氨基噻唑衍生物

成冲云,姜凤超*   

  1. (华中科技大学同济医学院药学院 武汉 430030)
  • 收稿日期:2004-10-15 修回日期:2005-01-24 发布日期:2005-06-30
  • 通讯作者: 姜凤超

Solvent Free Synthesis of 2-Aminothiazole Derivatives under Microwave Irradiation

CHENG Chong-Yun,JIANG Feng-Chao*   

  1. (School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030)
  • Received:2004-10-15 Revised:2005-01-24 Published:2005-06-30
  • Contact: JIANG Feng-Chao

在无溶剂条件下, 用微波辐射法以碘、酮和硫脲为原料合成了9个2-氨基噻唑衍生物. 利用正交法优化了微波促进此类环化反应的最佳条件, 提出了微波条件下碘催化环化合成2-氨基噻唑衍生物可能的反应机理.

关键词: 2-氨基噻唑衍生物, 反应机理, 合成, 微波辐射, 环化反应

Nine 2-aminothiazole derivatives were obtained under microwave irradiation condition by the reaction of thiourea, iodine and ketone in the absence of solvent. The reaction conditions were optimized by orthogonal design. The mechanism of the cyclization reaction under microwave irradiation was also suggested.

Key words: microwave irradiation, cyclization, reaction mechanism, synthesis, 2-aminothiazole