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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (9): 1057-1061. 上一篇    下一篇

研究论文

4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征

李鹏飞，王宝雷，马宁，王素华，李正名*   

  1. (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2004-08-16 修回日期:2005-03-23 发布日期:2005-08-24
  • 通讯作者: 李正名

Synthesis and Characterization of New 4-(Substituted pyrimidin-2-yl)- 1-(substituted benzenesulfonyl)semicarbazides

LI Peng-Fei,WANG Bao-Lei,MA Ning,WANG Su-Hua,LI Zheng-Ming*   

  1. (State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry,
  • Received:2004-08-16 Revised:2005-03-23 Published:2005-08-24
  • Contact: LI Zheng-Ming

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以取代的苯磺酰肼与(取代嘧啶-2-基)-氨基甲酸苯酯在非亲核性碱存在下合成了12个4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物5和3个5与碱形成的有机盐5as, 5bs和5cs. 所有合成化合物均经过元素分析和1H NMR的结构确证. 1H NMR数据证明, 在5as～5cs中, 磺酰氨基脲起到提供质子的作用.

关键词: 磺酰氨基脲, 合成, 有机盐

Nucleophilic reaction of phenyl (substituted pyrimidin-2-yl)-carbamate with benzenesulfonyl hydrazine in the presence of DBU or DABCO afforded the title compounds 4-(substituted pyrimidin-2-yl)-1- (substituted benzenesulfonyl)semicarbazides 5. Three organic salts 5as～5cs formed from 5 and DBU or DABCO were also obtained. Structures of 5 and their salts were determined by elemental analysis and 1H NMR spectra. The characteristic chemical shifts of 1H NMR of such salts were discussed.

Key words: synthesis, organic salt, sulfonyl semicarbazide