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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (9): 1062-1065. 上一篇    下一篇

研究论文

新型无毒离子液体催化“一锅煮”合成3,4-二氢嘧啶-2(1H)-酮

李明*,1，郭维斯1，文丽荣1，张秀丽2   

  1. (1青岛科技大学化学与分子工程学院 青岛 266042)
    (2中国海洋大学海洋药物与食品学院 青岛 266003)
  • 收稿日期:2004-12-17 修回日期:2005-03-25 发布日期:2005-08-24
  • 通讯作者: 李明

One-pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Nontoxic Ionic Liquid

LI Ming*,1,GUO Wei-Si1,WEN Li-Rong1,ZHANG Xiu-Li2   

  1. (1 College of Chemistry and Molecular Engineering, Qingdao University of Science and Technol-ogy, Qingdao 266042)
    (2 Institute of Marine Drug and Food, Ocean University of China, Qingdao 266003)
  • Received:2004-12-17 Revised:2005-03-25 Published:2005-08-24
  • Contact: LI Ming

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利用新型无毒离子液体(BMImSac)作催化剂, 芳香醛、1, 3-二羰基化合物和尿素或硫脲三组分“一锅煮”合成了3,4-二氢嘧啶-2(1H)-酮. 与传统方法相比, 该法是一种操作简单、产率高、用时少的环境友好方法.

关键词: 离子液体, Biginelli反应, 3, 4-二氢嘧啶-2(1H)-酮, 合成

3,4-Dihydropyrimidin-2(1H)-ones were synthesized via one-pot reaction of aldehydes, β-dicarbonyl compounds and urea or thiourea using nontoxic room temperature ionic liquid BMImSac as catalyst. Compared to the classical Biginelli reaction, this is a simple, highly-yielding, time-saving, and environmentally friendly method.

Key words: 3,4-dihydropyrimidin-2(1H)-ones, Biginelli reaction, synthesis, ionic liquid