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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (9): 1138-1141. 上一篇    下一篇

研究简报

KF/Al2O3催化下2-氨基-4-芳基-4H-吡喃并[3,2-c]香豆素衍生物的一步合成

王香善*,1,2,3，曾兆森1,3，史达清1,3，魏贤勇2，宗志敏2   

  1. (1徐州师范大学化学系 徐州 221116)
    (2中国矿业大学化学工程学院 徐州 221008)
    (3江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2004-10-25 修回日期:2005-04-12 发布日期:2005-08-24
  • 通讯作者: 王香善

One-pot Synthesis of 2-Amino-4-aryl-4H-pyrano[3,2-c]coumarinDe-rivatives Using KF/Al2O3 as Catalyst

WANG Xiang-Shan*,1,2,3,ZENG Zhao-Sen1,3,SHI Da-Qing1,3
WEI Xian-Yong2,ZONG Zhi-Min2   

  1. (1 Department of Chemistry, Xuzhou Normal University, Xuzhou, 221116)
    (2 School of Chemical Engineering, China University of Mining and Technol-ogy, Xuzhou 221008)
    (3 The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116)
  • Received:2004-10-25 Revised:2005-04-12 Published:2005-08-24
  • Contact: WANG Xiang-Shan

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以芳醛、4-羟基香豆素和丙二腈或氰乙酸酯为原料, 在KF/Al2O3催化下以乙醇为溶剂, 在80 ℃合成了一系列2-氨基-4-芳基-4H-吡喃并[3,2-c]香豆素衍生物, 并通过IR, 1H NMR和元素分析确证产物的结构.

关键词: 吡喃并[3, 2-c]香豆素, 4-羟基香豆素, KF/Al2O3, 合成

A series of 2-amino-4-aryl-4H-pyrano[3,2-c]coumarin derivatives were synthesized by the reaction of arylaldehyde, malononitrile or ethyl cyanoacetate with 4-hydroxycoumarin in ethyl alcohol at 80 ℃ catalyzed by KF-Al2O3. The structures of the products were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: synthesis, 4-hydroxycoumarin, KF-Al2O3, pyrano[3,2-c]coumarin