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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (03): 346-348. 上一篇    下一篇

研究论文

在离子液体中一步法合成吡唑[5,4-b]-γ-吡喃衍生物

李玉玲，杜百祥，王香善*，曾兆森，史达清，屠树江   

  1. (徐州师范大学化学系 江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2005-06-24 修回日期:2005-10-19 发布日期:2006-02-28
  • 通讯作者: 王香善

One Pot Synthesis of Pyrazolo[5,4-b]-γ-pyran Deriva-tives inIonic Liquid

LI Yu-Ling,DU Bai-Xiang, WANG Xiang-Shan*
ZENG Zhao-Sen,SHI Da-Qing,TU Shu-Jiang   

  1. (Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant of
    Jiangsu Province, Xuzhou 221116)
  • Received:2005-06-24 Revised:2005-10-19 Published:2006-02-28
  • Contact: WANG Xiang-Shan

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芳醛、丙二腈与4,5-二氢-3-甲基-5-氧代-1-苯基吡唑在离子液体[bmim][BF4]中反应, 合成了2-氨基-4-芳基-3-氰基-5-甲基-7-苯基吡唑[5,4-b]-γ-吡喃衍生物, 该法快速、高效, 是一种洁净的合成方法. 产物的结构通过红外光谱、核磁共振氢谱和元素分析进行表征.

关键词: 吡唑[5,4-b]-γ-吡喃, 离子液体, 合成

2-Amino-4-aryl-3-cyano-5-methyl-7-phenylpyrazolo[5,4-b]-γ-pyran derivatives were synthe-sized by the reaction of aromatic aldehydes, malononitrile and 4,5-dihydro-3-methyl-5-oxo-1- phenylpyra-zole in ionic liquid [bmim][BF4], which provided a fast, efficient and clean method. The structures of the product were characterized by IR, 1H NMR spectra and elemental analyses.

Key words: ionic liquid, synthesis, pyrazolo[5,4-b]-γ-pyran