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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (03): 383-386. 上一篇    下一篇

研究简报

N-(取代)对三氟甲基苯基-1,3,5-三取代吡唑-4-酰胺衍生物的合成与生物活性

杜海堂1,2，欧阳贵平*,1，杜海军1，史大斌1，金林红   

  1. (1贵州大学精细化工研究开发中心 贵阳 550025)
    (2贵阳医学院药学系 贵阳 550004)
  • 收稿日期:2004-12-16 修回日期:2005-09-14 发布日期:2006-02-28
  • 通讯作者: 欧阳贵平

Synthesis and Biological Activity of N-(Substi-tuted-p-trifluoromethyl-phenyl)-1,3,5-trisubstituted-pyrazole-4-carboxamide Derivatives

DUHai-Tang1,2,OUYANG Gui-Ping*,1,DU Hai-Jun1,SHI Da-Bin1,JIN Lin-Honga   

  1. (1 Research and Development Center of Fine Chemicals, Guizhou University, Guiyang 550025)
    (2 Department of Pharmacy, Guiyang Medical College, Guiyang 550004)
  • Received:2004-12-16 Revised:2005-09-14 Published:2006-02-28
  • Contact: OUYANG Gui-Ping

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被引次数

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设计合成10个未见文献报道的N-对三氟甲基苯基-1,3,5-三取代吡唑-4-酰胺类化合物, 其结构经元素分析, 1H NMR, IR 确证. 初步生物活性测试结果表明, 部分化合物对水稻纹枯病、小麦赤霉病、辣椒枯萎病和马铃薯晚疫病有一定的杀菌活性.

关键词: 对三氟甲基苯胺, 杀菌活性, 合成, 吡唑酰胺

In order to find novel fungicides with high activity and low toxicity, ten new N-(substituted-p- trifluoromethylphenyl)-1,3,5-trisubstituted-pyrazole-4-carboxamide de-rivatives were synthesized. Their structures were characterized by IR, 1H NMR spectra and elemental analysis. Preliminary bioassays indicated that some compounds showed fungicidal activity against Rhizoctonia sasakii, Gibberella zeae, Fusariun oxysporum, Phytophthora in-festans

Key words: fungicidal activity, synthesis, p-trifluoromethyl-phenylamine, pyrazolecarboxamide