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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (07): 942-945. 上一篇    下一篇

研究论文

微波作用下合成双(苯并咪唑-2-基)甲烷衍生物

孙亚伟，段桂运，刘俊芝，王建武*   

  1. (山东大学化学与化工学院 济南 250100)
  • 收稿日期:2005-11-02 修回日期:2006-01-16 发布日期:2006-07-01
  • 通讯作者: 王建武

Microwave Enhanced Synthesis of Bis(benzimidazol-2-yl)methane Derivatives

SUN Ya-Wei,DUAN Gui-Yun,LIU Jun-Zhi,WANG Jian-Wu*   

  1. (School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100)
  • Received:2005-11-02 Revised:2006-01-16 Published:2006-07-01
  • Contact: WANG Jian-Wu

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1175

被引次数

27 | 1

在无溶剂、无催化剂存在条件下, 用微波促进5-取代-1H-苯并咪唑-2-乙酸乙酯和4-取代-1,2-邻苯二胺反应, 合成了取代双(苯并咪唑-2-基)甲烷衍生物, 产率均在80%以上. 产物结构经IR, 1H NMR, MS等进行了表征.

关键词: 微波辐射, 5-取代-1H-苯并咪唑-2-乙酸乙酯, 合成, 双(苯并咪唑-2-基)甲烷

The microwave enhanced synthesis of bis(substituted benzimidazol-2-yl)methanes from ethyl 2-(5-substitutent-1H-benzimidazol-2-yl)acetate and 4-substituted phenylene-1,2-diamine under solvent-free condition without catalyst was achieved in good yields. Their structures were characterized by IR, 1H NMR and MS spectra.

Key words: ethyl 2-(5-substitutent-1H-benzimidazol-2-yl)acetate, bis(benzimidazol- 2-yl)-methane, synthesis, microwave irradiation