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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (07): 975-978. 上一篇    下一篇

研究简报

研磨法合成1,2,3,6-四氢嘧啶-2-酮衍生物

靳通收*，赵莹，刘利宾，李同双   

  1. (河北大学化学与环境科学学院 保定 071002)
  • 收稿日期:2005-06-14 修回日期:2006-01-18 发布日期:2006-07-01
  • 通讯作者: 靳通收

Synthesis of 1,2,3,6-Tetrahydropyrimidin-2-one Derivatives by Grinding Method

JIN Tong-Shou*,ZHAO Ying,LIU Li-Bin,LI Tong-Shuang   

  1. (College of Chemistry and Environmental Science, Hebei University, Baoding 071002)
  • Received:2005-06-14 Revised:2006-01-18 Published:2006-07-01
  • Contact: JIN Tong-Shou

PDF

1014

被引次数

31

以NH2SO3H为催化剂, 室温无溶剂条件下, 研磨芳醛、β-酮酸酯和尿素合成了一系列1,2,3,6-四氢嘧啶-2-酮衍生物. 该方法具有反应条件温和、操作简便、环境友好、产率高等优点.

关键词: 合成, 研磨, NH2SO3H, 1,2,3,6-四氢嘧啶-2-酮

NH2SO3H was used to efficiently perform one-pot, three-component, Biginelli condensation reactions of aldehydes, β-ketoesters and urea under solvent-free conditions at room temperature by grinding method. The method offered several advantages including mild reaction conditions, simple experimental procedure, environmental friendliness and excellent yield.

Key words: synthesis, grinding method, 1,2,3,6-tetrahydropyrimidin-2-one, aminosulfonic acid