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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (08): 1120-1124. 上一篇    下一篇

研究简报

1-(嘧啶基-4)-3-(2,6-二氟苯甲酰基)脲衍生物的合成与生物活性

魏振中1,2，庞怀林2,3，柳爱平*,2，程华1,2，凌立志2,3
刘洋1,2，胡春华1,2，杨光富1   

  1. (1华中师范大学化学学院农药与化学生物学教育部重点实验室 武汉 430079)
    (2湖南化工研究院国家南方农药创制中心湖南基地 长沙 410007)
    (3湖南师范大学化学化工学院 长沙 410081)
  • 收稿日期:2005-10-08 修回日期:2006-02-22 发布日期:2006-07-26
  • 通讯作者: 柳爱平

Synthesis and Biological Activity of 1-(Pyrimidin-4-yl)-3- (2,6-difluorobenzoyl)urea Derivatives

WEI Zhen-Zhong1,2,PANG Huai-Lin2,3,LIU Ai-Ping*,2,CHENG Hua1,2
LIN Li-Zhi2,3,LIU Yang1,2,HU Chun-Hua1,2,YANG Guang-Fu1

  1. (1 Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry,
    Central China Normal University, Wuhan 430079)
    (2 Hunan Branch of National Pesticide Research and Development South Center,
    Hunan Research Institute of Chemical Industry, Changsha 410007)
    (3 College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081)
  • Received:2005-10-08 Revised:2006-02-22 Published:2006-07-26
  • Contact: LIU Ai-Ping

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1015

被引次数

35

为了寻找高效、低毒、低残留的环境友好杀虫剂, 设计并合成了12个新的1-(嘧啶基-4)-3-(2,6-二氟苯甲酰基)脲衍生物6a～6l, 其结构经IR, 1H NMR, LC/MS和元素分析确证. 初步生物活性测试结果表明, 部分化合物具有明显的杀虫活性, 如6g在100 mg/L浓度下, 对粘虫(Mythimna sepatara)具有100%的杀虫活性.

关键词: 苯甲酰脲, 嘧啶, 生物活性, 合成

In an attempt to find novel pesticides with high activity, low toxicity and low residue, a series of novel 1-(pyrimidin-4-yl)-3-(2,6-difluorobenzoyl)urea derivatives 6a～6l were designed and synthesized. Their structures were confirmed by IR, 1H NMR, LC/MS spectra and elemental analysis. The results of preliminary bioassay showed that some title compounds possessed obvious insecticidal activity, e.g. 6g showed 100% biological activity against Mythimna sepatara at 100 mg/L.

Key words: pyrimidine, synthesis, biological activity, benzoylurea