有机化学 ›› 2006, Vol. 26 ›› Issue (11): 1548-1552. 上一篇    下一篇

研究论文

1-取代异喹啉合成新方法的研究

陈国英,卢胜梅,周永贵*   

  1. (中国科学院大连化学物理研究所 大连 116023)
  • 收稿日期:2006-02-14 修回日期:1900-01-01 发布日期:2006-10-27
  • 通讯作者: 周永贵

A New Synthetic Method of 1-Substituted Isoquinolines

CHEN Guo-Ying,LU Sheng-Mei,ZHOU Yong-Gui*   

  1. (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023)
  • Received:2006-02-14 Revised:1900-01-01 Published:2006-10-27
  • Contact: ZHOU Yong-Gui

在氯代甲酸苄酯活化下, 利用格氏试剂对异喹啉进行亲核加成, 得到1-取代-2-苄氧羰基-1,2-二氢异喹啉, 然后在Pd/C/HCO2NH4体系中进行芳构化, 得到1-取代异喹啉. 采用同样的方法, 一些2-取代的喹啉也能被合成.

关键词: 亲核加成, 钯碳, 芳构化

A series of 1-substituted isoquinolines were synthesized through the nucleophilic addition reaction of Grignard reagents to isoquinolines under the activation of benzyl chloroformate and aromatization in the presence of Pd/C.

Key words: Pd/C, aromatization, nucleophilic addition