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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (11): 1571-1575. 上一篇    下一篇

研究论文

新型含芳氧乙酸酯基三唑酮类化合物的合成及生物活性研究

卢彦昌，刘建兵，梁华，史延年，方建新*   

  1. (南开大学元素有机化学国家重点实验室 元素有机化学研究所 天津 300071)
  • 收稿日期:2005-11-15 修回日期:1900-01-01 发布日期:2006-10-27
  • 通讯作者: 方建新

Synthesis and Biological Activities of 1H-1,2,4-Triazole Derivatives Containing Aryloxyacetate Unit

LU Yan-Chang,LIU Jian-Bing,LIANG Hua,SHI Yan-Nian,FANG Jian-Xin*   

  1. (Institute and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071)
  • Received:2005-11-15 Revised:1900-01-01 Published:2006-10-27
  • Contact: FANG Jian-Xin

PDF

854

被引次数

42 | 8

通过芳氧乙酸与2-溴-4,4-二甲基-1-(1H-1,2,4-三唑-1-基)-3-戊酮反应, 合成了14个新型含芳氧乙酸酯基三唑酮类化合物. 所有化合物均经核磁、元素分析确证, 部分化合物进行了红外和质谱的测定. 生物活性测试表明部分化合物具有良好的生物活性.

关键词: 1H-1,2,4-三唑, 芳氧乙酸酯, 生物活性, 合成

Fourteen new 1H-1,2,4-triazole derivatives containing aryloxyacetate unit were synthesized by the reaction of 2-bromo-4,4-dimethyl-1-(1H-1,2,4-triazol-1-yl)pentan-3-one with substituted phenoxyacetic acid derivatives, the structures of which have been characterized by 1H NMR and elemental analysis. Bioassay showed that some of them exhibited high biological activities.

Key words: aryloxyacetate, synthesis, biological activity, 1H-1,2,4-triazole