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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (02): 188-196. 上一篇    下一篇

综述与进展

基于非生物折叠体的分子识别

李昌治a，蒋锡夔b，黎占亭*,b，高翔a，王全瑞*,a   

  1. (a复旦大学化学系 上海 200433)
    (b中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032)
  • 收稿日期:2005-09-14 修回日期:2006-06-19 发布日期:2007-01-30
  • 通讯作者: 王全瑞

Foldamer-Based Molecular Recognition

LI Chang-Zhia, JIANG Xi-Kuib, LI Zhan-Ting*,b, GAO Xianga, WANG Quan-Rui*,a   

  1. (a Department of Chemistry, Fudan University, Shanghai 200433)
    (b State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemis-try,
    Chinese Academy of Sciences, Shanghai 200032)
  • Received:2005-09-14 Revised:2006-06-19 Published:2007-01-30
  • Contact: WANG Quan-Rui

PDF

787

被引次数

10 | 3

利用分子自组装的方法控制大分子量的线性有机分子的构象是物理有机化学一个富于挑战性的研究课题. 近年来, 化学家已经成功利用不同的分子内非共价键作用力如氢键和疏溶剂作用等诱导线性分子的折叠乃至螺旋构象的产生. 综述了近年来这种新的非生物二级结构形式在分子识别研究中的应用.

关键词: 分子折叠体, 二级结构, 分子识别, 疏溶剂作用, 氢键

One of the challenging fields in physical organic chemistry is the control of the conformation of large linear organic molecules. In recent years, different non-covalent forces, especially hydrogen bonding and hydrophobic interaction, have been successfully applied to induce the folded or helical conformations of linear organic molecules. This paper reviews the recent applications of this new class of non-biological secondary structures in molecular recognition.

Key words: hydrogen bonding, hydrophobic interaction, secondary structure, molecular recognition, foldamer