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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (02): 218-2221. 上一篇    下一篇

研究论文

O-磷酸-L-丝氨酸及其衍生物的合成

张建臣*,a，曹书霞b，赵军峰b，廖新成b，赵玉芬b,c   

  1. (a北京防化指挥工程学院化学防护系 北京 102205)
    (b郑州大学有机化学及化学生物学重点实验室 郑州 450052)
    (c清华大学生命有机磷化学与化学生物学教育部重点实验室 北京 100084)
  • 收稿日期:2006-02-06 修回日期:2006-03-24 发布日期:2007-01-30
  • 通讯作者: 张建臣

Synthesis of O-Phospho-L-serine and Its Derivatives

ZHANG Jian-Chen*,a, CAO Shu-Xiab, ZHAO Jun-Fengb
LIAO Xin-Chengb, ZHAO Yu-Fenb,c   

  1. (a Department of Chemical Defense, Institute of Chemical Defense, Beijing 102205)
    (b Key Laboratory of Organic Chemistry and Chemical Biology, Zhengzhou Uni-versity, Zhengzhou 450052)
    (c Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education,
    Tsinghua University, Beijing 100084)
  • Received:2006-02-06 Revised:2006-03-24 Published:2007-01-30
  • Contact: ZHANG Jian-Chen*<

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介绍具有重要药理和生物活性的O-磷酸-L-丝氨酸及衍生物的合成. O-磷酸-L-丝氨酸通过部分水解的三氯氧磷与L-丝氨酸反应制得, 并培养得到了其晶体, 利用X射线衍射方法测定了它的晶体结构; 进而合成了O-磷酸-L-丝氨酸钙盐和O-磷酸-L-丝氨酸单(或双)二异丙胺盐. 产物经核磁共振、红外光谱和质谱进行了结构表征.

关键词: L-丝氨酸, O-磷酸-L-丝氨酸, 衍生物, 合成

O-Phospho-L-serine and its derivatives, having important pharmacology activity and bioactivity, were synthesized by the reaction of phosphorusoxychloride partially prehydrolyzed and L-serine. The crystal of O-phospho-L-serine was incubated and the crystal structure was determined by X-ray single crystal diffraction method. Furthermore, calcium salt, diisopropylamine salt and di(diisopropylamine) salt of O-phospho-L-serine were also synthesized. The structures of products were identified by NMR, IR and MS spectra.

Key words: O-phospho-L-serine, synthesis, derivative, L-serine