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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (04): 519-523. 上一篇    下一篇

研究简报

一锅法有效合成氨基甲酸酯类化合物

李立清*,a，王晓刚b，郭三霞b，刘重洋b，何益波b   

  1. (a中南大学能源科学与工程学院 长沙 410083)
    (b湖南大学环境科学与工程学院 长沙 410082)
  • 收稿日期:2006-06-05 修回日期:1900-01-01 发布日期:2007-03-29
  • 通讯作者: 李立清

One-Pot Synthesis of Carbamate

LI Li-Qing*,a, WANG Xiao-Gangb, GUO San-Xiab, LIU Chong-Yangb, HE Yi-Bob   

  • Received:2006-06-05 Revised:1900-01-01 Published:2007-03-29
  • Contact: LI Li-Qing

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被引次数

15 | 5

以四甲基胍(TMG)为催化剂, 乙腈(ACT)为溶剂, 利用CO2、胺和烷基氯三组分在0.10 MPa, 70～80 ℃条件下, 一锅法有效合成氨基甲酸酯类化合物, 并研究了收率和产率的影响. 结果表明, 最优反应条件为n(胺)∶n(烷基氯)＝3～4、反应温度70～80 ℃、反应时间2～3 h、酯分离收率达68.7%～81.3%, 酯纯度达到99.9%

关键词: 亲核取代反应, 位阻效应, 氨基甲酸酯, CO2

Carbamates were prepared by one-pot synthesis from carbon dioxide, amine and alkyl chloride with N,N,N,N-tetramethyl guanidine (TMG) as catalyst, acetonitrile (ACT) as solvents at a pressure of 0.10 MPa and temperature of 70～80 ℃. Effects of the converting ratio and yield were investigated. The results showed that the optimum technological conditions should be that n(amine)∶n(alkyl chloride)＝3～4, the reaction temperature was 70～80 ℃, and reaction time was 2～3 h. The purity of the refined of carbamates was 99.9%, and the yield of carbamates was in the range of 68.7%～81.3%.

Key words: steric effect, carbon dioxide, nucleophile substitution, carbamate