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有机化学 ›› 2007, Vol. 27 ›› Issue (07): 852-856. 上一篇    下一篇

研究论文

微波促进的5-氯-3-甲基-1-苯基-4-吡唑甲醛与氯化N-苯乙酮基吡啶及芳酰肼的缩合反应

张奉民，蔡习美，陈伟锋，颜朝国*   

  • 收稿日期:2006-05-29 修回日期:1900-01-01 发布日期:2007-06-30
  • 通讯作者: 颜朝国*

Microwave Irradiated Condensation Reaction of 5-Chloro-3-methyl- 1-phenyl-4-pyrazolecarboaldehyde with N-Phenacylpyridinium Chloride and Acetophenone

ZHANG Feng-Min,CAI Xi-Mei,CHEN Wei-Feng,YAN Chao-Guo*   

  1. (Analytical Center, College of Chemistry & Chemical Engineering, Yangzhou 225002)
  • Received:2006-05-29 Revised:1900-01-01 Published:2007-06-30
  • Contact: YAN Chao-Guo*

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5-氯-3-甲基-1-苯基-4-吡唑甲醛(1)在微波辐射下, 与氯化N-苯乙酮基吡啶(2)和取代苯乙酮3在醋酸铵/醋酸体系中一锅煮反应, 高产率地生成了吡唑基取代的吡啶衍生物4a～4e. 1与芳酰肼在微波辐射下反应, 则形成了酰腙类化合物6a～6g. 1与羟胺在微波辐射下缩合可生成肟7a和腈7b的混合物.

关键词: 微波辐射, 酰腙, 缩合反应, 吡唑, 吡啶

In the system of ammonium acetate and acetic acid under microwave irradiation, 5-chloro-3- methyl-1-phenyl-4-pyrazolecarboaldehyde (1) reacted with N-phenacylpyridinium chloride (2) and acetophenone 3 to give pyrazolyl substituted pyridine 4a～4e in high yields. 1 reacted with some aromatic acylhydrazines 5 to give acylhydrazone derivatives 6a～6g, while reacted with hydroxyamine to give a mixture of oxime 7a and nitrile 7b.

Key words: pyrazole, condensation reaction, hydrazone, pyridine, microwave irradiation