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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (07): 880-884. 上一篇    下一篇

研究简报

水-盐酸两步法分离瓜环混合物

毕强*，胡英鹏，杨琴，马彩莲，李东亮   

  1. (西安建筑科技大学理学院 西安 710055)
  • 收稿日期:2006-07-07 修回日期:1900-01-01 发布日期:2007-06-30
  • 通讯作者: 毕强*

A Two-Step Approach for Cucurbit[n]uril Compound Separating by Water and Hydrochloric Acid

BI Qiang*,HU Ying-Peng,YANG Qin,MA Cai-Lian,LI Dong-Liang   

  1. (School of Science, Xi'an University of Architecture and Technology, Xi'an 710055)
  • Received:2006-07-07 Revised:1900-01-01 Published:2007-06-30
  • Contact: BI Qiang*

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1515

被引次数

60 | 9

根据各元瓜环在水和盐酸两种溶剂中溶解度的不同, 提出了一种通过水-盐酸两步分离混合瓜环的方法. 探讨了溶剂用量、盐酸浓度等因素对分离效果的影响, 确定了最佳的分离工艺条件, 使CB[5], CB[6], CB[7]和CB[8]的分离产率分别达到78.9%, 92.0%, 88.0%和75.0%. 分离得到的瓜环单体经核磁共振检测, 纯度在95%以上, 其中CB[5]的纯度达到98%. 研究结果表明, 本工艺是一种简单有效的分离混合瓜环的方法.

关键词: 瓜环, 两步法, 分离, 水-盐酸, 核磁共振

This article developed a two-step separating approach of cucurbit[n]uril compound, which was based on the different solubility of cucurbit[n]uril in water and hydrochloric acid. Several factors of separating were deliberated and the optimized separating conditions were fixed. The productivity of CB[5], CB[6], CB[7] and CB[8] is 78.9%, 92.0%, 88.0% and 75.0% respectively. The purity of cucurbit[n]uril is higher than 95% determined by NMR spectra. Especially for CB[5], the detected purity is up to 98%. The results proved the discussed method to be a simple and reliable CB[n] monomers separating process.

Key words: water and hydrochloric acid, separating, two-step approach, nuclear magnetic resonance, cucurbit[n]uril