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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (11): 1309-1317.    下一篇

综述与进展

手性2-氨基-1-苯基乙醇类化合物的不对称合成研究进展

赵圣印   

  1. (东华大学化学与化工学院 上海 201620)
  • 收稿日期:2006-08-31 修回日期:2007-03-07 发布日期:2007-10-20
  • 通讯作者: 赵圣印

Recent Development in the Asymmetric Synthesis of Optically Active 2-Amino-1-phenylethanol Derivatives

ZHAO Sheng-Yin   

  1. (College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620)
  • Received:2006-08-31 Revised:2007-03-07 Published:2007-10-20
  • Contact: ZHAO Sheng-Yin

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被引次数

23 | 2

对近年来手性2-氨基-1-苯基乙醇类药物的不对称合成方法进行了总结和概述. 重点介绍了不对称氢化、CBS还原、不对称Henry反应等新方法在2-氨基-1-苯基乙醇类药物如R-沙丁胺醇、R-沙美特罗和D-索他洛尔等合成中的应用.

关键词: 手性2-氨基-1-苯基乙醇, 不对称合成, R-沙丁胺醇, R-沙美特罗

The main asymmetric synthetic methods for optically active 2-amino-1-phenylethanol derivatives are summarized according to reaction type such as asymmetric hydrogenation, CBS-oxazaborolidine reduction and Henry reaction, especially for the synthetic methodology of R-salbutamol, R-salmeterol and D-sotalol.

Key words: asymmetric synthesis, R-salbutamol, R-salmeterol, optically active 2-amino-1-phenylethanol