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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (11): 1420-1423. 上一篇    下一篇

研究简报

三乙基苄基氯化铵催化下水介质中吡喃并[2,3-d]嘧啶衍生物的一步合成

梁静*,a，张梅梅b，魏贤勇a，宗志敏a，王香善b   

  1. (a中国矿业大学化工学院 徐州 221116)
    (b徐州师范大学化学系 徐州 221116)
  • 收稿日期:2007-03-07 修回日期:2007-05-24 发布日期:2007-10-20
  • 通讯作者: 梁静

One-Step Syntheses of Pyrano[2,3-d]pyrimidine Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride

LIANG Jing*,a,ZHANG Mei-Meib,WEI Xian-Yonga
ZONG Zhi-Mina,WANG Xiang-Shanb   

  1. (a School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116)
    (b Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
  • Received:2007-03-07 Revised:2007-05-24 Published:2007-10-20
  • Contact: LIANG Jing

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以芳亚甲基丙二腈、1,3-二甲基巴比妥酸为原料, 以水为溶剂, 在100 ℃以三乙基苄基氯化铵(TEBAC)为催化剂合成了一系列的吡喃并[2,3-d]嘧啶衍生物, 该方法具有反应条件温和, 产率良好(78%～90%)和环境友好等优点. 产物的结构通过IR, 1H NMR和元素分析表征, 并进一步通过X射线衍射分析确证.

关键词: 吡喃并[2,3-d]嘧啶, TEBAC, 水, 合成

A series of pyrano[2,3-d]pyrimidine derivatives were synthesized from arylidene malononitrile and 1,3-dimethyl barbital at 100 ℃ catalyzed by triethylbenzylammonium chloride (TEBAC) in water. This method has many advantages, such as mild reaction conditions, high yields (78%～90%) and environmental friendliness. The structures of the products were characterized by IR, 1H NMR spectra and elemental analyses, and further confirmed by X-ray diffraction analysis.

Key words: triethylbenzylammonium chloride, water, synthesis, pyrano[2,3-d]pyrimidine