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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (12): 1530-1536. 上一篇    下一篇

研究论文

3-取代苄氧基-6-取代氨基哒嗪衍生物的合成及其除草活性

胡方中，张敏，朱有全，邹小毛，刘斌，杨华铮*   

  1. (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2007-01-19 修回日期:2007-05-14 发布日期:2007-12-04
  • 通讯作者: 杨华铮

Synthesis and Herbicidal Activity of 3-(Substituted benzyloxy)- 6-(substituted amino)pyridazines

HU Fang-Zhong, ZHANG Min, ZHU You-Quan
ZOU Xiao-Mao, LIU Bin, YANG Hua-Zheng*   

  1. (State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University,
    Tianjin 300071)
  • Received:2007-01-19 Revised:2007-05-14 Published:2007-12-04
  • Contact: YANG Hua-Zheng

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1059

被引次数

7 | 1

通过3-取代苄氧基-6-氟哒嗪在75～80 ℃与二甲胺的绝对无水乙醇溶液封管反应, 或在回流条件下分别与吗啡啉或哌啶反应, 合成一系列新颖的3-取代苄氧基-6-取代氨基哒嗪类化合物, 它们的结构均经IR, 1H NMR和元素分析确证. 初步的除草活性测定结果表明, 该类化合物具有一定的除草活性, 讨论了它们的结构与除草活性的关系.

关键词: 3-取代苄氧基-6-取代氨基哒嗪, 合成, 除草活性, 构效关系

A series of new 3-(substituted benzyloxy)-6-(substituted amino)pyridazines were synthesized through the reaction of 3-(substituted benzyloxy)-6-fluoropyridazines with the solution of dimethylamine in absolute ethanol in a sealed tube in 75～80 ℃ or with morpholine or piperidine under reflux, respectively. The title compounds were identified by IR, 1H NMR spectra and elemental analyses. Preliminary bioassay showed that some of them had certain extent herbicidal activities, and the structure-activity relationship was also discussed.

Key words: synthesis, herbicidal activity, structure- activity relationship, 3-(substituted benzyloxy)-6-(substituted amino)pyridazine